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METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE (AD) USING THE MOLECULES THAT STABILIZE INTRACELLULAR CALCIUM (Ca2+) RELEASE
METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE (AD) USING THE MOLECULES THAT STABILIZE INTRACELLULAR CALCIUM (Ca2+) RELEASE
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机译:使用稳定细胞内钙(Ca2 +)释放的分子诊断和治疗老年痴呆症(AD)的方法
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摘要
The subject technology relates, in part, to a method of treating Alzheimer's Disease (AD), early-stage AD, elevated risk of AD, mild cognitive impairment (MCI), or other forms of age-related cognitive decline in a subject in need thereof by administering to the subject a molecule that promotes calcium-release stabilization in ryanodine receptors (RyRs) and/or inosital triphosphate receptors (InsP3Rs) in brain cells. Diagnostic methods using calcium-release stabilizing immunophilins, junctophilins or calmodulin are also disclosed.
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