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Methods for Broad-Stability Mass Analysis Using a Quadrupole Mass Filter

机译:使用四极杆质量过滤器进行广泛稳定性质量分析的方法

摘要

A method of mass analysis comprises: generating ions from the sample; delivering the ions to a quadrupole; applying a radio frequency voltage, V, to rods of the quadrupole such that the instantaneous electrical potential of each rod is out of phase with each adjacent rod and a non-oscillatory voltage, U, across each pair of adjacent rods such that a subset of the ions having a range of mass-to-charge (m/z) ratios are selectively transmitted through the quadrupole; varying at least one of voltage U and voltage V such that the range of selectively transmitted m/z ratios is caused to vary and varying at least one additional operational parameter; acquiring a data set comprising a series of temporally-resolved images of spatial distribution patterns of transmitted ions at each combination of U, V and the at least one additional operating parameter; and mathematically deconvolving the data set to generate mass spectra.
机译:质量分析的方法包括:从样品中产生离子;将离子输送到四极杆;向四极杆施加射频电压V,以使每个杆的瞬时电势与每个相邻杆异相,并且在每对相邻杆之间施加非振荡电压U,以使具有质荷比(m / z)范围的离子选择性地通过四极传输。改变电压U和电压V中的至少一个,以使得选择性传输的m / z比的范围改变并且改变至少一个另外的操作参数;获取数据集,该数据集包括在U,V和至少一个附加操作参数的每种组合下的一系列透射离子的空间分辨图案的时间分辨图像;并对数据集进行数学解卷积以生成质谱图。

著录项

  • 公开/公告号US2016314950A1

    专利类型

  • 公开/公告日2016-10-27

    原文格式PDF

  • 申请/专利权人 THERMO FINNIGAN LLC;

    申请/专利号US201514696237

  • 发明设计人 JOHNATHAN WAYNE SMITH;ALAN E. SCHOEN;

    申请日2015-04-24

  • 分类号H01J49;H01J49/42;

  • 国家 US

  • 入库时间 2022-08-21 14:38:47

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