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Induced precancerous stem cell or induced malignant stem cell capable of self-replication in vitro, production method thereof, and application of these cells
Induced precancerous stem cell or induced malignant stem cell capable of self-replication in vitro, production method thereof, and application of these cells
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机译：能够在体外自我复制的诱导的癌前干细胞或诱导的恶性干细胞，其制备方法和这些细胞的应用
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摘要
The present invention provides an induced cancer cell capable of self-replication in vitro which is useful in cancer therapy research and the research for cancer-related drug discovery, processes for production thereof, cancer cells induced by the malignant cells, and applications of these cells. The present invention provides an induced cancer stem cell capable of proliferation (self-replication) in vitro, wherein the induced cancer stem cell has the following two characteristics: (1) expressing the six genes (self-renewal related genes) POU5F1, NANOG, SOX2, ZFP42, LIN28, and TERT selected from a certain group of genes; and (2) having an aberration which is either (a) a mutation in an endogenous tumor suppressor gene or (b) increased expression of an endogenous cancer-related gene.
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