首页> 外国专利> INDUCED MALIGNANT STEM CELLS OR PRE-INDUCTION CANCER STEM CELLS CAPABLE OF SELF-REPLICATION OUTSIDE OF AN ORGANISM, PRODUCTION METHOD FOR SAME, AND PRACTICAL APPLICATION FOR SAME

INDUCED MALIGNANT STEM CELLS OR PRE-INDUCTION CANCER STEM CELLS CAPABLE OF SELF-REPLICATION OUTSIDE OF AN ORGANISM, PRODUCTION METHOD FOR SAME, AND PRACTICAL APPLICATION FOR SAME

机译：能在有机体内自我复制的恶性干细胞或诱导前癌干细胞，其制备方法，以及实际应用

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摘要

The present invention provides an induced cancer cell capable of self-replication in vitro which is useful in cancer therapy research and the research for cancer-related drug discovery, processes for production thereof, cancer cells induced by the malignant cells, and applications of these cells. The present invention provides an induced cancer stem cell capable of proliferation (self-replication) in vitro, wherein the induced cancer stem cell has the following two characteristics: (1) expressing the six genes (self-renewal related genes) POU5F1, NANOG, SOX2, ZFP42, LIN28, and TERT selected from a certain group of genes; and (2) having an aberration which is either (a) a mutation in an endogenous tumor suppressor gene or (b) increased expression of an endogenous cancer-related gene.

机译：本发明提供了一种能够在体外自我复制的诱导癌细胞，其可用于癌症治疗研究以及与癌症有关的药物发现，其生产方法，由恶性细胞诱导的癌细胞以及这些细胞的应用的研究。。本发明提供了一种能够在体外增殖（自我复制）的诱导癌干细胞，其中所述诱导癌干细胞具有以下两个特征：（1）表达选自特定基因组的六个基因（自我更新相关基因）POU5F1，NANOG，SOX2，ZFP42，LIN28和TERT;和（2）畸变要么是（a）内源性肿瘤抑制基因的突变，要么是（b）内源性癌症相关基因的表达增加。

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公开/公告号EP2599860A4

专利类型
公开/公告日2013-11-20

原文格式PDF
申请/专利权人 NATIONAL CANCER CENTER;
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申请/专利号EP20110786682
发明设计人 ISHIKAWA TETSUYA;
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申请日2011-05-25
分类号C12N5/10;A01K67/027;A61K39;C12N15/09;C12Q1/02;G01N33/15;G01N33/50;
国家 EP
入库时间 2022-08-21 15:48:38

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