首页> 外国专利> TARGET MOLECULE WHICH INDUCES MATURE NEURON DEATH BY BINDING OF AMYLOSPHEROID, METHOD AND SUBSTANCE WHICH INHIBIT NEURON DEATH INDUCED BY AMYLOSPHEROID, AND USE THEREOF

TARGET MOLECULE WHICH INDUCES MATURE NEURON DEATH BY BINDING OF AMYLOSPHEROID, METHOD AND SUBSTANCE WHICH INHIBIT NEURON DEATH INDUCED BY AMYLOSPHEROID, AND USE THEREOF

机译：通过结合类淀粉体诱导成人神经元死亡的分子，方法和物质，以抑制类淀粉体诱导神经元死亡，并利用它们

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摘要

PROBLEM TO BE SOLVED: To provide a target molecule inducing cell death by binding of amylospheroid, a target molecule of amylospheroid expressed in mature neurons in one or more embodiments, and to provide a method and substance which inhibit mature neuron death induced by amylospheroid in one or more embodiments.SOLUTION: In one aspect, the invention relates to a use of Na/K-ATPase3 as a binding target molecule of amylospheroid. In other aspects, the invention relates to a method for inhibiting mature neuron death induced by amylospheroid, such as a method which comprises inhibiting protein interaction between amylospheroid and Na/K-ATPase3.

机译：解决的问题：在一个或多个实施方案中，提供通过结合类淀粉样蛋白，在成熟神经元中表达的类淀粉样蛋白的靶分子来诱导细胞死亡的靶分子，以及提供一种在一种或多种实施方式中抑制由类淀粉样蛋白诱导的成熟神经元死亡的方法和物质。解决方案：一方面，本发明涉及Na / K-ATPase3作为淀粉样球蛋白的结合靶分子的用途。在其他方面，本发明涉及抑制由淀粉样球蛋白诱导的成熟神经元死亡的方法，例如包括抑制淀粉样球蛋白和Na / K-ATPase3之间的蛋白质相互作用的方法。

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公开/公告号JP2015214557A

专利类型
公开/公告日2015-12-03

原文格式PDF
申请/专利权人 TAO HEALTH LIFE PHARMA CO LTD;
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申请/专利号JP20150123236
发明设计人 HOSHI MINAKO;
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申请日2015-06-18
分类号A61K38;C12Q1/42;C12Q1/04;C07K14;C07K5/10;C07K7;C12N15/09;A61K31/7088;A61K45;A61P25/28;G01N33/566;G01N33/50;G01N33/15;A61K49;
国家 JP
入库时间 2022-08-21 14:44:45

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