首页> 外国专利> BIOMARKER FOR DETERMINING MALIGNANCY OF CANCER, AND PROGNOSIS AND/OR EFFECTIVENESS OF ANTICANCER AGENT TREATMENT, COMPANION DIAGNOSTIC AGENT FOR SELECTING ANTICANCER AGENT, AS WELL AS ANTICANCER AGENT

BIOMARKER FOR DETERMINING MALIGNANCY OF CANCER, AND PROGNOSIS AND/OR EFFECTIVENESS OF ANTICANCER AGENT TREATMENT, COMPANION DIAGNOSTIC AGENT FOR SELECTING ANTICANCER AGENT, AS WELL AS ANTICANCER AGENT

机译:用于确定癌症的恶性程度的生物标志物,以及抗癌剂治疗的预后和/或功效,用于选择抗癌剂的伴侣诊断剂以及抗癌剂

摘要

PROBLEM TO BE SOLVED: To provide a biomarker for determining the malignancy of cancer, and the prognosis and/or effectiveness of an anticancer agent treatment, to provide a method for determining, using miR, the malignancy of cancer, and the prognosis and/or effectiveness of the anticancer agent treatment, as well as to provide a companion diagnostic agent or anticancer agent containing miR.SOLUTION: The invention relates to a method of using a biomarker that can determine the malignancy of cancer, and the prognosis and/or the effectiveness of anticancer agent treatment, while considering a patient's immune status, the biomarker being one or more kinds of microRNAs that exhibit a characteristic expression pattern in a patient with an IL-6 high expression level in blood. The invention also relates to a biomarker that can utilize, as anticancer agents, either a specified miR, and an inhibitory nucleic acid against this or a functional equivalent thereof that can inhibit the growth of cancer cells by being introduced into the cancer cells.SELECTED DRAWING: Figure 1
机译:要解决的问题:提供用于确定癌症恶性以及抗癌剂治疗的预后和/或有效性的生物标志物,以提供使用miR确定癌症恶性,预后和/或预后的方法抗癌剂治疗的有效性,以及提供含miR的伴随诊断剂或抗癌剂。解决方案:本发明涉及使用可以确定癌症恶性程度,预后和/或有效性的生物标志物的方法。在考虑患者的免疫状态的同时,生物标志物是一种或多种在血液中具有IL-6高表达水平的患者中表现出特征性表达模式的微RNA。本发明还涉及一种生物标志物,其可以利用特定的miR作为抗癌剂,并且可以使用针对其或其功能等价物的抑制性核酸,所述抑制性核酸可以通过被引入癌细胞来抑制癌细胞的生长。 : 图1

著录项

  • 公开/公告号JP2016158525A

    专利类型

  • 公开/公告日2016-09-05

    原文格式PDF

  • 申请/专利权人 HOKKAIDO UNIV;

    申请/专利号JP20150038360

  • 申请日2015-02-27

  • 分类号C12Q1/68;G01N33/53;G01N33/574;A61P35/00;A61K48/00;A61P1/00;A61K31/7105;

  • 国家 JP

  • 入库时间 2022-08-21 14:47:05

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