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NANOPARTICLE STRUCTURES, FABRICATION, METHODS, AND APPLICATIONS IN CHEMICAL AND BIOLOGICAL SENSING
NANOPARTICLE STRUCTURES, FABRICATION, METHODS, AND APPLICATIONS IN CHEMICAL AND BIOLOGICAL SENSING
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机译:纳米颗粒的结构,结构,方法及其在化学和生物传感中的应用
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摘要
This disclosure provides, among other things, a method for enhancing detection of an analyte that is bound to a substrate comprising a signal amplification layer on a surface of the substrate, wherein the signal amplification layer comprises high-amplification regions and low-amplification regions, and the high-amplification regions amplify signals at said surface more than the low-amplification regions. The method comprises selectively masking the low-amplification regions of the substrate, thereby increasing the probability that an analyte will bind to a high-amplification region and be detected.
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