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首页> 外国专利> COMPOSITIONS AND METHODS FOR IDENTIFYING AND DIAGNOSING SALT SENSITIVITY OF BLOOD PRESSURE

COMPOSITIONS AND METHODS FOR IDENTIFYING AND DIAGNOSING SALT SENSITIVITY OF BLOOD PRESSURE

机译：用于确定和诊断血压的盐敏感性的组合物和方法

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It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ≧7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.
机译：确定SLC4A5中的SNP是否与血压的盐敏感性（BP）相关。受试者食用等热量的恒定饮食，随机顺序为7天低Na +（10 mmol / d）和7天高Na +（300 mmol / d）摄入量。盐敏感性定义为平均动脉压（MAP）增加≥7 mm Hg。分析了17个候选基因中的35个多态性。与盐敏感性的关联分析显示了三个与盐敏感性相关的变体，其中两个在SLC4A5中（rs7571842，rs10177833; P <0.001），而一个在GRK4中（rs1801058; P = 0.020）。还发现，响应盐摄入量变化而引起的血压反常变化与DRD2的SNP有关（rs6276）。总之，SLC4A5变异与高加索人对BP的盐敏感性密切相关，而DRD2 SNP是对盐摄入矛盾的标志。

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