首页> 外国专利> CARTILAGE-SPECIFIC HIF-2 TRANSGENIC MOUSE AS AN ANIMAL MODEL FOR ARTHRITIS, AND USE THEREOF

CARTILAGE-SPECIFIC HIF-2 TRANSGENIC MOUSE AS AN ANIMAL MODEL FOR ARTHRITIS, AND USE THEREOF

机译:特定于关节炎的HIF-2转基因小鼠作为关节炎的动物模型及其用途

摘要

The present invention relates to a transgenic fertilized egg in which expression constructs, excluding human expression constructs, are introduced, including: (a) a nucleotide sequence encoding hypoxia-inducible factor 2α (HIF-2 α); and (b) a transcription-regulating sequence which is operatively linked to the nucleotide sequence, as well as to a transgenic animal model for arthritis obtained therefrom. A transgenic mouse transformed with a recombinant expression vector of the present invention may be very useful as a therapeutic model for arthritis, which may be used in studies on the cartilage degeneration process. In addition, the transgenic mouse of the present invention may be applied to a method for screening arthritis therapeutics.
机译:本发明涉及一种转基因受精卵,其中引入了除人表达构建体以外的表达构建体,包括:(a)编码缺氧诱导因子2α(HIF-2α)的核苷酸序列; (b)与核苷酸序列可操作地连接的转录调节序列,以及与由此获得的关节炎的转基因动物模型。用本发明的重组表达载体转化的转基因小鼠作为关节炎的治疗模型可能是非常有用的,其可以用于软骨变性过程的研究。另外,本发明的转基因小鼠可以应用于筛选关节炎治疗剂的方法。

著录项

  • 公开/公告号EP2573169B1

    专利类型

  • 公开/公告日2016-10-26

    原文格式PDF

  • 申请/专利权人 KWANGJU INST SCI & TECH;

    申请/专利号EP20100851841

  • 发明设计人 CHUN JANG-SOO;YANG SI YOUNG;

    申请日2010-12-08

  • 分类号C12N5/10;C12N15/85;C12N5/073;A01K67/027;C07K14/47;

  • 国家 EP

  • 入库时间 2022-08-21 14:53:19

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