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IMPROVEMENT METHOD OF GENE NETWORK USING DOMAIN-SPECIFIC PHYLOGENETIC PROFILES SIMILARITY

机译:基于域特定系统发育相似度的基因网络改进方法

摘要

The present invention relates to a method for improving a gene network using a domain-specific PPS. The domain-specific PPS for two mutual dependent genes is measured in a signal transmission path by the method according to the present invention. The signal transmission path of the gene in a body is efficiently reconstructed by using the domain-specific PPS for the gene according to the present invention. Also, similarity between the phylogenetic profiles of the genes which are commonly inherited is accurately measured by combining the gene network based on the domain-specific PPS according to the present invention. The gene related to the diseases of a human is predicted by using the constructed gene network.
机译:本发明涉及使用域特异性PPS改善基因网络的方法。通过根据本发明的方法在信号传输路径中测量两个相互依赖的基因的域特异性PPS。通过使用根据本发明的基因的结构域特异性PPS,可以有效地重建体内基因的信号传递路径。而且,通过组合基于本发明的结构域特异性PPS的基因网络,可以准确地测量通常遗传的基因的系统发育谱之间的相似性。通过使用构建的基因网络可以预测与人类疾病相关的基因。

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