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ANTI-TISSUE INHIBITOR OF METALLOPROTEINASE-4 (TIMP-4) ANTIBODIES AND METHODS OF USE THEREOF

机译:金属蛋白酶4(TIMP-4)抗体的抗组织抑制剂及其使用方法

摘要

Compositions and methods for treating diseases and disorders expressing tissue inhibitor of metalloproteinase-4 (TIMP-4) are provided. In accordance with the present invention, novel antibody molecules and fragments thereof immunologically specific for TIMP-4 are provided. In a particular embodiment, the disease or disorder is cancer, particularly breast, brain, ovarian, and/or esophageal cancer, or osteoarthritis, or cardiovascular disease. In a particular embodiment, the cancer over-expresses TIMP-4 and/or has aberrant TIMP-4 activity/function, e.g., overactivity. The methods comprise administering a therapeutically effective amount of the anti-TIMP-4 antibodies of the invention to a subject, e.g.,' as part of a pharmaceutical preparation.
机译:提供了用于治疗表达金属蛋白酶-4组织抑制剂(TIMP-4)的疾病和病症的组合物和方法。根据本发明,提供了对TIMP-4具有免疫学特异性的新型抗体分子及其片段。在一个特定的实施方案中,该疾病或病症是癌症,特别是乳腺癌,脑癌,卵巢癌和/或食道癌,或骨关节炎或心血管疾病。在一个特定的实施方案中,癌症过度表达TIMP-4和/或具有异常的TIMP-4活性/功能,例如过度活性。所述方法包括例如向受试者施用治疗有效量的本发明的抗TIMP-4抗体,例如作为药物制剂的一部分。

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