首页> 外国专利> VACCINES FOR INTRANASAL USE AGAINST STREPTOCOCCUS PYOGENES USING AN INNOCUOUS BACTERIAL VECTOR AND SPECIFIC ANTIGENS

VACCINES FOR INTRANASAL USE AGAINST STREPTOCOCCUS PYOGENES USING AN INNOCUOUS BACTERIAL VECTOR AND SPECIFIC ANTIGENS

机译：使用无毒的细菌载体和特定的抗生素对链球菌脓杆菌进行鼻内使用疫苗

展开▼

页面导航

摘要

著录项

相似文献

摘要

The invention relates to an immunogenic formulation for prompting an immune response in a subject, said formulation comprising: a mixture of genetically modified, non-pathogenic strains of bacteria, each expressing a different hypervariable segment of the M protein of Streptococcus pyogenes; and a biologically acceptable diluent. The invention also relates to the use of the immunogenic formulation for preparing an intranasally administered vaccine, and to a method for producing said vaccine. 展开▼

机译：本发明涉及用于在受试者中促进免疫应答的免疫原性制剂，所述制剂包含：遗传修饰的，非致病性菌株的混合物，所述菌株各自表达化脓性链球菌的M蛋白的不同的高变区段。 / I>;和生物学上可接受的稀释剂。本发明还涉及免疫原性制剂在制备鼻内施用的疫苗中的用途，以及生产所述疫苗的方法。展开▼

著录项

公开/公告号WO2015044909A1

专利类型

公开/公告日2015-04-02

原文格式PDF

申请/专利权人 PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE;
展开▼

申请/专利号WO2014IB64870

发明设计人 WOZNIAK BANCHERO ANIELA;GARCÍA CAÑETE PATRICIA;AGUIRRE URRUTIA DANIEL;
展开▼

申请日2014-09-26

分类号C12N15/31;A61K39/09;

国家 WO

入库时间 2022-08-21 15:07:30

相似文献

专利

外文文献

中文文献

1. 来自棒杆菌属细菌的新的启动子核酸、包含该启动子的表达盒和包含该表达盒的载体、包含该载体的宿主细胞和使用该细胞表达基因的方法 [P] . 中国专利： CN101087880B . 2011.05.11

2. 来自棒杆菌属细菌的新的启动子核酸、包含该启动子的表达盒和包含该表达盒的载体、包含该载体的宿主细胞和使用该细胞表达基因的方法 [P] . 中国专利： CN101712956B . 2011.12.21

3. Nasal vaccines against Streptococcus pyogenes in vector based on a safe and specific bacterial Antigens, method for producing them [P] . AR097790A1 . 2016-04-13

机译：基于安全和特异性细菌抗原的载体中化脓性链球菌鼻疫苗及其生产方法

4. Isolated polynucleotide, vector comprising this polynucleotide, vector transformed or transfected host cell, method for production of isolated polypeptide coded by isolated polynucleotide, composition for vaccines comprising this polypeptide, the use of this composition in treating or preventing streptococcus infection, diagnostic test method for streptococcus infection, detection method for antibody specifically binding to streptococcus antigen, detection method for streptococci presence in biological sample [P] . PL204073B1 . 2009-12-31

机译：分离的多核苷酸，包含该多核苷酸的载体，载体转化或转染的宿主细胞，生产由分离的多核苷酸编码的分离的多肽的方法，用于包含该多肽的疫苗的组合物，该组合物在治疗或预防链球菌感染中的用途，链球菌的诊断测试方法感染，特异性结合链球菌抗原的抗体的检测方法，生物样品中链球菌的存在的检测方法

5. COMBINED INACTIVATED VACCINE AGAINST BACTERIAL DISEASES IN FISH COMPRISING ANTIGEN ORIGINATED FROM STREPTOCOCCUS PARAUBERIS AND PREVENTION METHOD OF BACTERIAL DISEASES IN FISH USING IT [P] . 韩国专利： KR101603714B1 . 2016-03-17

机译：包含副产链球菌抗原的鱼中细菌灭活的联合灭活疫苗及用其预防鱼中细菌病的方法

1. Using Bacterial Vectors for Probable Vaccines: From Molecular Mechanism to Cancer Therapy [J] . Parnia Jabbari 疫苗（英文） . 2020,第002期

2. Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies tofightthe infection [J] . Zainularifeen Abduljaleel, Faisal A.Al-Allaf, Syed A.Aziz 生物设计与制作(英文) . 2021,第003期

3. Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation [J] . Olive C, Schulze K, Sun HK, Vaccine . 2007,第10期

4. Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose [J] . Zhang Ming, Dong Chunsheng, Xiong Sidong Frontiers in Cellular and Infection Microbiology . 2017,第2008期

5. Upregulation of capsule enables Streptococcus pyogenes to evade immune recognition by antigen-specific antibodies directed to the G-related α2-macroglobulin-binding protein GRAB located on the bacterial surface [J] . Katrin Dinkla, Inka Sastalla, Antonia W. Godehardt, Microbes and infection . 2007,第8期

6. Peptide amphiphile micelles as a vaccine platform for Streptococcus pyogenes [C] . John Barrett, Matthew V Tirrell World biomaterials congress . 2016

7. Rescue of dysfunctional endogenous T cells by an antigen-specific bacterial vaccine. [D] . Binder, David Charles. 2013

8. Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose [O] . Ming Zhang, Chunsheng Dong, Sidong Xiong 2017

9. Vesicular Stomatitis Virus-Vectored Multi-Antigen Tuberculosis Vaccine Limits Bacterial Proliferation in Mice following a Single Intranasal Dose [O] . Ming Zhang, Chunsheng Dong, Sidong Xiong 2017

1. Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies to fight the infection [J] . Zainularifeen Abduljaleel ,Faisal A.Al-Allaf ,Syed A.Aziz . 生物设计与制造 . 2021,第003期

2. Anti-tumor effects induced by gene vaccines co-expressing truncated human prostate specific membrane antigen gene and mouse 4-1BBL [J] . 匡幼林 . 外科研究与新技术 . 2011,第4期

3. Hsp70-1ike protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD^8＋ CTL response by dendritic cell vaccine [J] . Wu Y Wan T Zhou X Wang B Yang F Li N Chen G Dai S Liu S Zhang M Cao X . 第二军医大学学报 . 2006,第1期

4. 病例报告：荷兰自繁自养猪场口服接种胞内劳森氏菌疫苗与使用抗生素的生产性能相似 [C] . M.Schlepers ,周远成 . 第22届国际猪兽医协会大会（IPVS2012） . 2012

5. 对使用代理器服务器进行特定网站访问的电子特证提取方法研究与实现 [A] . 刘昆 . 2011