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首页> 外文期刊>Vaccine >Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation
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Enhanced protection against Streptococcus pyogenes infection by intranasal vaccination with a dual antigen component M protein/SfbI lipid core peptide vaccine formulation

机译：通过双重抗原成分M蛋白/ SfbI脂质核心肽疫苗制剂的鼻内疫苗接种，增强了针对化脓性链球菌感染的保护

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摘要

We investigated the efficacy of a synthetic Streptococcus pyogenes vaccine targeting two virulence factors using the Lipid Core Peptide (LCP) delivery system. BALB/c mice were immunised intranasally with LCPs containing peptides encompassing T-cell and B-cell epitopes of the conserved C-repeat region of the M protein (J8) or the fibronectin-binding repeats region (FNBR) of SfbI, or a combination formulation containing peptides representing both antigens. LCPs were co-administered with the TLR2/6 agonist MALP-2 as mucosal adjuvant. Humoral and cellular immune responses stimulated at systemic and mucosal levels were strongest in mice immunised with the dual antigen formulation. Mice were completely protected following a respiratory challenge with a lethal dose of a heterologous S. pyogenes strain, whereas there was 70% and 90% survival in mice immunised with LCP-J8 and LCP-FNBR, respectively. This is the first report demonstrating the elicitation of better protective immunity by a dual antigen component S. pyogenes vaccine.
机译：我们使用脂质核心肽（LCP）输送系统调查了针对两种毒力因子的化脓性链球菌合成疫苗的功效。用含肽的LCP鼻内免疫BALB / c小鼠，该肽包含M蛋白（J8）的保守C重复区或SfbI的纤连蛋白结合重复区（FNBR）的T细胞和B细胞表位，或其组合含有代表两种抗原的肽的制剂。 LCP与TLR2 / 6激动剂MALP-2作为粘膜佐剂共同给药。在用双重抗原制剂免疫的小鼠中，在全身和粘膜水平刺激的体液和细胞免疫反应最强。致死剂量的异源化脓性链球菌菌株在呼吸道攻击后完全保护了小鼠，而用LCP-J8和LCP-FNBR免疫的小鼠分别有70％和90％的存活率。这是第一份证明双重抗原成分化脓性链球菌疫苗引发更好的保护性免疫的报告。

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