首页> 外国专利> A METHOD FOR ALTERING THE CD4/CD8 RATIO AND THE MONONUCLEAR CELLULAR INFILTRATE INTO A TUMOR

A METHOD FOR ALTERING THE CD4/CD8 RATIO AND THE MONONUCLEAR CELLULAR INFILTRATE INTO A TUMOR

机译:一种改变CD4 / CD8比例和单核细胞浸润成肿瘤的方法

摘要

A method for altering the CD4/CD8 ratio and the mononuclear cellular infiltrate into a tumor that results in significant modulation of the infiltrating immune cells shown by a decrease in CD8+ T cells and a significant increase in tumor infiltrating CD4+ T cells. A dose of 800 IU/day as IL-2 for 5 days per week for 3 weeks of a Leukocyte Interleukin Injection (LI) being a serum-free and mitogen-free mixture comprised of specific ratios of cytokines IL-1beta, TNF-alpha, IFN-gamma and GM-CSF to Interleukin 2 (IL-2) resulted in a paradigm shift. The paradigm shift is defined as a marked CD4+ T cell infiltrate and a clear and specific change in the density and localization of antigen presenting cells such as dendritic cells and inflammatory cells, particularly neutrophils in cancer nests.
机译:一种改变CD4 / CD8比率和单核细胞浸润进入肿瘤的方法,该方法导致对浸润免疫细胞的显着调节,表现为CD8 + T细胞的减少和肿瘤浸润CD4 + T细胞的显着增加。白细胞白介素注射液(LI)的IL-2剂量为800 IU /天,每周3天,每周5天,是无血清和无促分裂原的混合物,由特定比例的细胞因子IL-1beta,TNF-alpha组成,IFN-γ和GM-CSF对白介素2(IL-2)的影响发生了范式转变。范式转变被定义为明显的CD4 + T细胞浸润,以及抗原呈递细胞(例如树突状细胞和炎性细胞,尤其是癌巢中的中性粒细胞)的密度和定位发生明显而特定的变化。

著录项

  • 公开/公告号EP1753452B1

    专利类型

  • 公开/公告日2015-10-28

    原文格式PDF

  • 申请/专利权人 CEL-SCI CORPORATION;

    申请/专利号EP20050756247

  • 发明设计人 TALOR EYAL;

    申请日2005-06-03

  • 分类号A01N37/18;A61K39;

  • 国家 EP

  • 入库时间 2022-08-21 15:09:02

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