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GLYCOMIC BIOMARKER OF RAT SERUM BASED ON MICROFLUIDIC CHIP-LC/MS

机译:基于微流控芯片-LC / MS的大鼠血清糖原生物标志物

摘要

#$%^&*AU2014101378A420141211.pdf#####ABSTRACT The present invention relates to a method of characterizing the serum N-glycome using microfluidic chip-LC-ESI-QTOF MS and MS/MS techniques for selection of the most appropriate animal model for pathological and pharmacological studies. The N-glycans of rat serum were comprehensively profiled using the newly developed technique. In total, 282 Nglycans, included isomers were identified among which 172 glycans were reported from rat serum for the first time, and 27 were novel glycans. 20Cl C) o U z o z .4 U z C.) U z U o U '0 o 0 - _____ oN Cl -z ~ rfl (~) -+ - - _________________ ____ ____ -2 ~flN Cl _ .4 -~ -~ C-) '0 z z U U Cl '0 U U t N ~r q~ - q~ tin C ~ 'p t r - CC '0 t Cl C o C-r ~t ~r1 o - - - C C 8 8 (s~uno~ uci) Avsueiui (siunco uoi) 4suemi C o a U Cl 7 U e 0 U U ~: -o .4 C-) U r. z z x U U '0 '0 U U ~ o ooooooo66 C 666o (s~unoj uoi) k!sueluI (siunos uoi) A1!sue~uI
机译:#$%^&* AU2014101378A420141211.pdf #####抽象用于表征血清N-糖基的方法技术领域微流控芯片LC-ESI-QTOF MS和MS / MS技术可供选择用于病理和药理研究的适当动物模型。大鼠的N-聚糖使用最新开发的技术对血清进行了全面分析。总计282 N鉴定了包括异构体在内的多种聚糖,其中大鼠报告了172种聚糖首次检测到血清,其中27种为新型聚糖。20氯C)o U zz.4英寸z C.)züØü'0o 0- _____ 上Cl -z〜rfl(〜)-+--_____________________ ____ -2〜flN Cl_ .4-〜-〜C-)'0Z ZU氯'0Ut N〜r q〜-q〜锡C〜'p t r-CC'0 t Cl Co C-r〜t〜r1 o---C C8 8(s〜uno〜uci)Avsueiui(siunco​​ uii)4suemiCaü氯7e0ü〜〜:-o.4C-)我们设U'0'0U〜o ooooooo66 C 666o(s〜unoj uii)k!sueluI(siunos uii)A1!sue〜uI

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