#$%^&*AU2011201420B220150813.pdf#####ABSTRACT 5 Disclosed herein are methods of modulating gastrointestinal gene expression. In one example, the disclosed method includes administering a composition comprising 01,3 (4)-endoglucanohydrolase, 3-1,3 (4)glucan, diatomaceous earth, mineral clay, and glucomannan under conditions sufficient to modulate one or more gastrointestinal genes in a human or animal species. The compositions can be fed to any mammalian or avian 10 species including, but not limited to, bovine, equine, ovine, caprine and avian species. When admixed with the feed or food or fed as a supplement, the composition can be used to regulate (e.g., up-regulate or down-regulate) one or more gastrointestinal genes, such as to induce or enhance energy metabolism genes, nutrient transport genes, or a combination thereof. The disclosed methods can also be used to regulate, such as 15 enhance or induce Type I and/or Type II antigen presentation and in turn inducement or enhancement of an immune response. 2619290_1 (GHMatters)
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