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DNA vaccine, the method of inducing an immune response, the antibody specifically recognizing the protein of the influenza virus hemagglutinin H5 and the use of DNA vaccine
DNA vaccine, the method of inducing an immune response, the antibody specifically recognizing the protein of the influenza virus hemagglutinin H5 and the use of DNA vaccine
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机译：DNA疫苗，诱导免疫反应的方法，特异性识别流感病毒血凝素H5蛋白的抗体以及DNA疫苗的用途
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摘要
The object of the invention is a DNA vaccine, method of inducing the immune response, antibodies specifically recognizing the haemagglutinin H5 of an influenza virus and application of the DNA vaccine. According to the invention, one or two-fold immunization of hens with DNA vaccine containing a cDNA encoding the modified H5 haemagglutinin HA protein, i.e. with the deletion of the cleavage site between HA subunits (this provides for greater safety of the vaccines). Moreover, the encoding region of the HA is modified in such a way that protein production in the bird cells should achieve maximal yield. The main modification is codon optimization for the hens and deletion of the site of proteolytic cleavage between subunits HA1 and HA2.
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