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Gamma related retinal (ROR gamma) receptor modulators for the treatment of autoimmune and inflammatory diseases

机译：γ相关的视网膜（RORγ）受体调节剂，用于治疗自身免疫和炎性疾病

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摘要

The invention refers to a formula compound as the modulator of gamma iris bone receptor and a formula compound for the treatment of rogamma vector diseases such as multiple sclerosis, rheumatoid arthritis and psychosis, wherein R1 is tar such as C1-C6, C3-C7, R2 is halogen or C1-C3 tar; R3 is halogen or methyl; R4 is h or methyl; R5 is C1-C3 tar; R6 is C1-C3 tar; R7 is C1-C7 tar, etc.; 0 or 1 per K; 0 or 1 per P. The preferred compounds are: (s) - N - (3 - ((4 - (cyclopentantan carbazone) - 3-methylpyridine-1-il) methyl) - 5-fluoro-2-methylphenyl) - 2-methylpyridine-5-carboxyamine (E20);Y (s) - N - (5-chloro-3 - ((4 - (cyclopentantan carbohydrates) - 3-methylpyridine-1-il) methyl) - 2-methylphenyl) - 6-methylnicotine (E62);Among other things

机译：本发明涉及作为伽马虹膜骨受体调节剂的配方化合物和用于治疗rog载体疾病如多发性硬化症，类风湿性关节炎和精神病的配方化合物，其中R1为焦油如C1-C6，C3-C7， R2是卤素或C1-C3焦油; R3是卤素或甲基; R4是h或甲基; R5为C1-C3焦油; R6为C1-C3焦油; R7是C1-C7焦油等;每K 0或1;每P为0或1。优选的化合物为：（s）-N-（3-（（4-（环戊烷碳烷）-3-甲基吡啶-1-il）甲基）-5-氟-2-甲基苯基）-2 -甲基吡啶-5-羧胺（E20）; Y（s）-N-（5-氯-3--（（4-（环戊烷碳水化合物）-3-甲基吡啶-1-il）甲基）-2-甲基苯基）-6 -甲基烟碱（E62）;除其他外

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公开/公告号PE20151144A1

专利类型
公开/公告日2015-08-02

原文格式PDF
申请/专利权人 GLAXO GROUP LIMITED;
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申请/专利号PE20120201500
发明设计人 HAN FANGBIN;LEI HUI;LIN XICHEN;MENG QINQHUA;WANG YONGHUI;
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申请日2013-12-05
分类号C07D403/12;A61K31/495;A61K31/496;A61K31/497;A61K31/501;A61K31/506;C07D241/04;C07D401/12;C07D401/14;C07D407/12;C07D413/12;C07D413/14;C07D417/12;C07D417/14;C07D471/04;
国家 PE
入库时间 2022-08-21 15:13:31

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