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Diagnostic tests for predicting prognosis recurrence resistance or sensitivity to therapy and metastatic status in cancer

机译:诊断测试可预测癌症的预后复发抵抗力或对治疗和转移状态的敏感性

摘要

pThe present invention describes a method utilizing a set of genes or gene products whose altered expression in cancer tissue particularly head and neck cancer and other carcinomas or its adjacent normal tissues predicts (a) probability of recurrence in time after treatment (b) sensitivity or resistance to therapies or (c) probability of metastasis at the time of initial discovery of the tumor. Furthermore the invention describes methods of determining the molecular signature in tumor tissues tissues adjacent to the tumor or in saliva by using DNA microarray techniques quantitative real time PCR immunohistochemistry or other methods that are used for determining gene or gene product expression levels./p
机译:本发明描述了一种利用一组基因或基因产物的方法,所述基因或基因产物的表达在癌组织中特别是在头颈癌和其他癌或其邻近的正常组织中的表达改变预测(a)治疗后及时复发的可能性(b)对治疗的敏感性或抵抗力,或(c)在最初发现肿瘤时转移的可能性。此外,本发明还描述了通过使用DNA微阵列技术,定量实时PCR免疫组织化学或用于确定基因或基因产物表达水平的其他方法来确定邻近肿瘤的组织或唾液中的分子标记的方法。

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