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首页> 外国专利> A. tau binding antibody; vector; parasite cell; hibridoma; peptide, including tau title; drug composition including tau antibody or peptide; medical equipment for managing these antibodies; drug for treating, preventing or diagnosing Alzheimer's disease or related Dow's disease; And methods of producing antibodies

A. tau binding antibody; vector; parasite cell; hibridoma; peptide, including tau title; drug composition including tau antibody or peptide; medical equipment for managing these antibodies; drug for treating, preventing or diagnosing Alzheimer's disease or related Dow's disease; And methods of producing antibodies

机译：A. tau结合抗体;向量;寄生细胞血吸虫病肽，包括tau标题;药物组合物，包括tau抗体或肽;用于管理这些抗体的医疗设备;用于治疗，预防或诊断阿尔茨海默氏病或​​相关道氏疾病的药物;以及产生抗体的方法

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The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
机译：本发明提供了独特的治疗和诊断抗体，以及它们的片段，部分，衍生物和变体，它们结合了有助于病理性tau-tau相互作用的起始和传播的tau蛋白区域，以及制备方法他们。本发明还涉及将那些抗体用于诊断，预防和治疗阿尔茨海默氏病和相关疾病的方法。本发明还提供了预防和治疗阿尔茨海默氏病和其他神经退行性疾病的方法。该方法需要注射抗体和/或肽疫苗，以引发针对患者脑中病理性tau蛋白和tau沉积物的免疫反应。合适的疫苗代表带有一个或多个本文提供的tau治疗性表位的tau肽。

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