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Implantable drug depot and method of treatment or prevention of postoperative pain in a patient

机译：植入式药物仓库以及治疗或预防患者术后疼痛的方法

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摘要

The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.
机译：本发明涉及可用于减轻，预防或治疗需要这种治疗的患者的术后疼痛的可植入药物贮库，该可植入药物贮库包含治疗有效量的可乐定或其可药用盐和聚合物。其中所述贮库可植入在皮肤下方的部位以减轻，预防或治疗术后疼痛，并且所述贮库相对于皮肤可释放（i）约5％至约45％的可乐定或其药学上可接受的盐。在最多48小时的第一时间段内装载在药物仓库中的可乐定或其可药用盐的总量，以及（ii）相对于可乐定或其可药用盐的总量的约55％至约95％在至少3天的随后时间内将可乐定或其药学上可接受的盐装载到药物仓库中。

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