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The autoantigenos mimetic peptides and their use in imunodiagnu00f3stico of juvenile idiopathic arthritis

机译：自身抗原模拟肽及其在青少年特发性关节炎免疫诊断中的应用

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The autoantigenos mimetic peptides and their use in imunodiagnu00f3stico of juvenile idiopathic arthritis. Juvenile idiopathic arthritis (JIA) is characterized by persistent arthritis of unknown cause that begins before the age of 16.At present, the diagnosis of Jia is based on clinical history and in the detection of rheumatoid factor, which has low specificity, sensitivity and its prognostic value is controversial.Due to the need of new diagnostic methods, the present invention has developed, from the lineage of mouse dba1 / J (a murine model of human rheumatoid arthritis), peptides that mimic autoantigenos present in AIJ.These peptides were selected from libraries displaying random peptides on the surface of the phage, which they called the antibodies purified from serum of mice with arthritis.The fourteen peptides obtained during selection were able to discriminate patients with Jia of healthy children and can be used potentially for the construction of new platforms for the early detection of AIJ.

机译：自身抗原模拟肽及其在青少年特发性关节炎的免疫诊断中的用途。幼年特发性关节炎（JIA）的特征是始于16岁之前的原因不明的持续性关节炎。目前，贾的诊断是基于临床病史和对类风湿因子的检测，其特异性，敏感性和敏感性较低。预后价值是有争议的。由于需要新的诊断方法，本发明从小鼠dba1 / J（人类风湿性关节炎的鼠模型）的血统发展了模拟AIJ中存在的自身抗原的肽。从噬菌体表面上显示随机肽的文库中选出的抗体，它们称为从关节炎小鼠血清中纯化的抗体。选择过程中获得的14种肽能够区分健康儿童的贾氏患者，可潜在地用于构建早期发现AIJ的新平台。

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公开/公告号BR102013017639A2

专利类型
公开/公告日2015-09-01

原文格式PDF
申请/专利权人 UNIVERSIDADE FEDERAL DE UBERLÂNDIA;FAPEMIG - FUNDAÇÃO DE AMPARO A PESQUISA DO ESTADODE MINAS GERAIS;
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申请/专利号BR20131017639
发明设计人 GALBER RODRIGUES ARAÚJO;LUIZ RICARDO GOULART FILHO;CARLOS HENRIQUE MARTINS DA SILVA;CARLOS UEIRA VIEIRA;PATRICIA TIEMI FUJIMURA;
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申请日2013-07-10
分类号C07K7/08;A61K38/10;A61P19/02;G01N33/564;
国家 BR
入库时间 2022-08-21 15:16:20

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