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Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof
Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof
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机译:具有扩增的人类白血病干细胞和白血病非干细胞的小鼠及其生产方法
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摘要
The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rgnull mouse by transplanting a substance containing a leukemic stem cell derived from a human acute myelogenous leukemia patient to the mouse. In addition, the invention relates to screening for a medicament capable of eradicating leukemic stem cell (LSC), consideration of treatment methods suitable for individual patients, identification of a differentially expressed gene and the like, using a mouse with expanded human leukemic cells.
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