首页> 外国专利> MULTIPLE BIOMARKER SET FOR BREAST CANCER DIAGNOSIS, METHOD OF DETECTING THE SAME, AND DIAGNOSIS KIT FOR BREAST CANCER USING ANTIBODY AGAINST THE SAME

MULTIPLE BIOMARKER SET FOR BREAST CANCER DIAGNOSIS, METHOD OF DETECTING THE SAME, AND DIAGNOSIS KIT FOR BREAST CANCER USING ANTIBODY AGAINST THE SAME

机译:用于乳腺癌诊断的多种生物标志物,检测方法以及使用针对抗体的抗体诊断乳腺癌的试剂盒

摘要

The present invention relates to a biomarker set for diagnosing breast cancer comprising two or more protein markers of: apolipoprotein C1, apolipoprotein (a), neural cell adhesion molecule L1-like protein, carbonic anhydrase 1, and fibronectin; a method for detecting the biomarker set in a blood sample through a multiple reaction monitoring; a kit for diagnosing breast cancer comprising antibodies specific to each of the proteins of the biomarker set; and a method for detecting proteins of the marker set in a blood sample through an antigen-antibody binding reaction. The method for detecting the protein marker set in a blood sample by the MRM method or antigen-antibody binding reaction and the diagnostic kit can provide very high accuracy and sensitivity in comparison with the diagnosis method using a single marker and can very conveniently diagnose breast cancer using blood from patients, thereby being effectively used for early diagnosis of breast cancer.
机译:本发明涉及一种用于诊断乳腺癌的生物标志物,其包含两种或更多种蛋白质标志物:载脂蛋白C1,载脂蛋白(a),神经细胞粘附分子L1样蛋白,碳酸酐酶1和纤连蛋白;一种通过多反应监测检测血样中生物标志物的方法;用于诊断乳腺癌的试剂盒,其包含对所述生物标志物组的每种蛋白质具有特异性的抗体;通过抗原-抗体结合反应检测血样中的标志物蛋白质的方法。与使用单一标记物的诊断方法相比,通过MRM法或抗原-抗体结合反应检测血样中蛋白质标记物的方法和诊断试剂盒可以提供非常高的准确性和敏感性。利用患者的血液,从而有效地用于乳腺癌的早期诊断。

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