首页> 外国专利> TREATMENT OF SPINAL CORD INJURY OR TRAUMATIC BRAIN INJURY BY INHIBITION OF AMYLOIDOGENIC PROTEINS AND SYNUCLEIN PROTEIN ACCUMULATION OR AGGREGATION

TREATMENT OF SPINAL CORD INJURY OR TRAUMATIC BRAIN INJURY BY INHIBITION OF AMYLOIDOGENIC PROTEINS AND SYNUCLEIN PROTEIN ACCUMULATION OR AGGREGATION

机译：抑制淀粉样蛋白原蛋白和突触核蛋白蛋白的积聚或聚集，治疗脊髓损伤或外伤性脑损伤

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摘要

Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins. Examples of treatments that may inhibit accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins include treatment with a synuclein antisense nucleobase oligomer or treatment with the molecular tweezers CLR01. These treatments may improve outcomes of spinal cord surgery or traumatic brain injury, including, without limitation, neuronal survival, neuronal regeneration, and recovery of neuronal functions.

机译：提供了治疗脊髓损伤或脑外伤的方法。在某些实施方案中，该方法包括使用能够抑制一种或多种淀粉样蛋白和/或突触核蛋白的积累或聚集的分子镊子和/或核碱基低聚物。可以抑制一种或多种淀粉样蛋白和/或突触核蛋白的积累或聚集的治疗方法的例子包括用突触核蛋白反义核苷碱基低聚物治疗或用分子镊子CLR01治疗。这些治疗可以改善脊髓手术或颅脑外伤的结果，包括但不限于神经元存活，神经元再生和神经元功能的恢复。

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公开/公告号US2015202222A1

专利类型
公开/公告日2015-07-23

原文格式PDF
申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;THE MARINE BIOLOGICAL LABORATORY;BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;
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申请/专利号US201414536176
发明设计人 JENNIFER R. MORGAN;GAL BITAN;DAVID J. BUSCH;
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申请日2014-11-07
分类号A61K31/7088;C12N15/113;A61K31/255;A61K31/194;A61K31/6615;A61K31/663;
国家 US
入库时间 2022-08-21 15:25:49

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