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MOLECULARLY IMPRINTED POLYMER NANOPARTICLES COMPATIBLE WITH BIOLOGICAL SAMPLES AND PREPARATION METHOD THEREOF
MOLECULARLY IMPRINTED POLYMER NANOPARTICLES COMPATIBLE WITH BIOLOGICAL SAMPLES AND PREPARATION METHOD THEREOF
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机译:兼容生物样品的分子印迹聚合物纳米粒子及其制备方法
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摘要
This invention provides molecularly imprinted polymer nanoparticles compatible with biological samples, and in particular pure biological samples and a preparation method thereof. Said molecularly imprinted polymer nanoparticles have a crosslinking degree exceeding 50%, a particle diameter of 10 to 500 nm, hydrophilic polymer brushes on its surfaces and can be prepared by introducing appropriate hydrophilic macromolecular chain transfer agents into reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization systems through the one-pot synthesis. The preparation method is simple, features a broad range of application and yields a pure product. The obtained hydrophilic molecularly imprinted polymer nanoparticles have prospects for a wide range of application in biological sample analysis, medical clinical immune analysis, food and environmental monitoring, biomimetic sensors, etc.
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