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MOLECULARLY IMPRINTED POLYMER NANOPARTICLES COMPATIBLE WITH BIOLOGICAL SAMPLES AND PREPARATION METHOD THEREOF

机译:兼容生物样品的分子印迹聚合物纳米粒子及其制备方法

摘要

This invention provides molecularly imprinted polymer nanoparticles compatible with biological samples, and in particular pure biological samples and a preparation method thereof. Said molecularly imprinted polymer nanoparticles have a crosslinking degree exceeding 50%, a particle diameter of 10 to 500 nm, hydrophilic polymer brushes on its surfaces and can be prepared by introducing appropriate hydrophilic macromolecular chain transfer agents into reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization systems through the one-pot synthesis. The preparation method is simple, features a broad range of application and yields a pure product. The obtained hydrophilic molecularly imprinted polymer nanoparticles have prospects for a wide range of application in biological sample analysis, medical clinical immune analysis, food and environmental monitoring, biomimetic sensors, etc.
机译:本发明提供了与生物样品,特别是纯生物样品相容的分子印迹聚合物纳米颗粒及其制备方法。所述分子印迹聚合物纳米颗粒的交联度超过50%,粒径为10至500nm,在其表面上具有亲水性聚合物刷,并且可以通过将适当的亲水性高分子链转移剂引入可逆的加成-断裂链转移(RAFT)中来制备。一锅法合成沉淀聚合体系。该制备方法简单,适用范围广,产品纯正。所获得的亲水性分子印迹聚合物纳米颗粒在生物样品分析,临床免疫分析,食品和环境监测,仿生传感器等方面具有广泛的应用前景。

著录项

  • 公开/公告号US2015299366A1

    专利类型

  • 公开/公告日2015-10-22

    原文格式PDF

  • 申请/专利权人 NANKAI UNIVERSITY;

    申请/专利号US201314646180

  • 发明设计人 YING ZHANG;YUE MA;GUOQING PAN;HUIQI ZHANG;

    申请日2013-11-20

  • 分类号C08F267/06;G01N33/543;

  • 国家 US

  • 入库时间 2022-08-21 15:27:13

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