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MOLECULARLY IMPRINTED POLYMER NANOPARTICLES ADAPTED TO BIOLOGICAL SAMPLES AND PREPARATION METHOD THEREOF

机译:适用于生物样品的分子印迹聚合物纳米粒子及其制备方法

摘要

Molecularly imprinted polymer nanoparticles adapted to biological samples, and in particular pure biological samples, and a preparation method therefor. The degree of crosslinking of said molecularly imprinted polymer nanoparticles exceeds 50%, particle diameters range from 10 to 500 nanometers, and surfaces feature a hydrophilic polymer brush; synthesis in a single-step is by reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization induced by a hydrophilic polymer chain transfer agent; the method of synthesis is simple, features a broad range of application and yields a pure product. The obtained hydrophilic molecularly imprinted polymer nanoparticles have prospects for a wide range of application in biological sample analysis, medical clinical immune analysis, food and environmental monitoring, biomimetic sensors, etc..
机译:适用于生物样品,尤其是纯生物样品的分子印迹聚合物纳米颗粒及其制备方法。所述分子印迹聚合物纳米颗粒的交联度超过50%,粒径范围为10至500纳米,并且表面具有亲水性聚合物刷。一步合成是通过亲水性聚合物链转移剂引起的可逆加成-断裂链转移(RAFT)沉淀聚合。该合成方法简单,具有广泛的应用范围,可得到纯净的产物。所获得的亲水性分子印迹聚合物纳米颗粒在生物样品分析,医学临床免疫分析,食品和环境监测,仿生传感器等方面具有广泛的应用前景。

著录项

  • 公开/公告号WO2014079367A1

    专利类型

  • 公开/公告日2014-05-30

    原文格式PDF

  • 申请/专利权人 NANKAI UNIVERSITY;

    申请/专利号WO2013CN87538

  • 发明设计人 ZHANG HUIQI;MA YUE;ZHANG YING;PAN GUOQING;

    申请日2013-11-20

  • 分类号C08F222/14;C08F226/06;C08F220/06;C08F2/38;C08J9/26;C08J9/28;B01J20/26;B01J20/30;

  • 国家 WO

  • 入库时间 2022-08-21 15:49:34

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