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首页> 外文期刊>Journal of the Taiwan Institute of Chemical Engineers >Preparation and evaluation of magnetic core-shell mesoporous molecularly imprinted polymers for selective adsorption of amitriptyline in biological samples
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Preparation and evaluation of magnetic core-shell mesoporous molecularly imprinted polymers for selective adsorption of amitriptyline in biological samples

机译：磁芯 - 壳介孔分子印迹聚合物的制备与评价，用于选择性吸附生物样品中的阿米替林

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In this study, preparation of magnetic surface molecular imprinted polymer (MMIP) is employed for sensitive solid phase extraction and measurement of amitriptyline (AMT) by spectrophotometric technique. After polymerization, cavities in the polymer particles corresponding to the AMT were created by leaching the polymer by an appropriate solution. The synthesized nanoparticles of magnetic surface molecular imprinted polymer mesoparticles (Fe3O4@SiO2-MIP) were characterized by transfer electron microscopy (TEM), vibrating sample magnetometer (VSM), Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD) and Brunauer-Emmett-Teller (BET). Also, the pH of zero-point charge (pH(zpc)) for Fe3O4@SiO2-MIP was determined with the pH drift method. The influence of various parameters such as pH, amount of polymer and contact time were investigated by an optimization technique named Box-Behnken design (BBD) and the proposed quadratic model was fitted very well with the experimental data. The validity of optimum parameters and the equation of parameters were investigated by analysis of variance (ANOVA). Also Scatchard isotherm was explored for the equilibrium adsorption investigation and finally, the prepared polymer was successfully applied to the selective identification and the determination of AMT in plasma samples. (C) 2018 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
机译：在该研究中，通过分光光度法使用磁性表面分子压印聚合物（MMIP）的制备用于敏感固相提取和氨基百分之一（AMT）的测量。聚合后，通过通过适当的溶液浸出聚合物，产生与AMT对应的聚合物颗粒中的空腔。通过转移电子显微镜（TEM），振动样品仪（VSM），傅里叶变换红外光谱（FTIR），X射线衍射（XRD），X射线衍射（XRD）和傅立叶衍射（XRD）和Brunauer-Emmett-Teller（赌注）。此外，用pH漂移法测定Fe3O4-MIP的零点电荷（pH（ZPC））的pH值。通过名为Box-Behnken Design（BBD）的优化技术研究了各种参数如pH，聚合物和接触时间的各种参数，并且用实验数据非常适合拟议的二次模型。通过分析方差（ANOVA）来研究最佳参数和参数方程的有效性。还探讨了Scatchard等温线用于平衡吸附调查，最后，成功地将制备的聚合物应用于选择性鉴定和测定血浆样品中的AMT。 （c）2018台湾化工工程师研究所。 elsevier b.v出版。保留所有权利。

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