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首页> 外国专利> Application of the tetrapeptide Arg-Pro-Gly-Pro as a means of prevention and treatment of hypercholesterolemia, method of prevention and treatment of hypercholesterolemia, the pharmaceutical composition for prevention and treatment of hypercholesterolemia and PROCESS FOR ITS PREPARATION

Application of the tetrapeptide Arg-Pro-Gly-Pro as a means of prevention and treatment of hypercholesterolemia, method of prevention and treatment of hypercholesterolemia, the pharmaceutical composition for prevention and treatment of hypercholesterolemia and PROCESS FOR ITS PREPARATION

机译：四肽Arg-Pro-Gly-Pro作为预防和治疗高胆固醇血症的方法，预防和治疗高胆固醇血症的方法，用于预防和治疗高胆固醇血症的药物组合物及其制备方法

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1. Application of the tetrapeptide Arg-Pro-Gly-Pro as a means of prevention and treatment giperholesterinemii.2. A method for preventing and treating hypercholesterolemia, comprising intranasal administration of the drug based on the tetrapeptide Arg-Pro-Gly-Pro in an effective kolichestve.3. A pharmaceutical composition for preventing and treating hypercholesterolemia, comprising a peptide having a cholesterol-lowering effect as an active substance and a pharmaceutically acceptable excipient as a preservative, characterized in that the peptide used in a peptide of general formula Arg-Pro-Gly-Pro, or a pharmaceutically acceptable salt thereof. 4. A composition according to claim 3, characterized in that the content of the peptide or a pharmaceutically acceptable salt thereof is 0.1 ÷ 1.0 wt.%. 5. A composition according to claim. 3 or 4, characterized in that it is suitable for intranasal vvedeniya.6. A composition according to claim 5, characterized in that it is formed as a solution with the following composition: peptide Arg-Pro-Gly-Pro, or a pharmaceutically acceptable salt - 1 ÷ 10 g / l; Nipagin - 0.9 ÷ 1.1 g / liter as preservative, distilled water - up to 1 l.7. A process for preparing a pharmaceutical composition for preventing and treating hypercholesterolemia, comprising mixing the active substances and excipients, characterized in that as active substance the peptide use the general formula Arg-Pro-Gly-Pro, or a pharmaceutically acceptable sol.8. A method according to claim 7, characterized in that the content of the peptide or a pharmaceutically acceptable salt thereof is 0.1 ÷ 1.0 wt.%. 9. A method according to claim 7 or 8, characterized in that the composition is prepared in a form suitable for intranasal vvedeniya.10. The method according to claim 9, of
机译：1.四肽Arg-Pro-Gly-Pro作为预防和治疗giperholesterinemii的手段的应用2。一种预防和治疗高胆固醇血症的方法，该方法包括在有效的胆汁中鼻内施用基于四肽Arg-Pro-Gly-Pro的药物。一种预防和治疗高胆固醇血症的药物组合物，其包含具有降低胆固醇作用的肽作为活性物质和药学上可接受的赋形剂作为防腐剂，其特征在于，所述肽用于通式为Arg-Pro-Gly-Pro的肽或其药学上可接受的盐。 4.根据权利要求3的组合物，其特征在于所述肽或其药学上可接受的盐的含量为0.1÷1.0重量％。 5.根据权利要求1的组合物。 3或4，其特征在于它适合于鼻内vvedeniya。6。 6.根据权利要求5所述的组合物，其特征在于，其形成为具有以下组成的溶液：肽Arg-Pro-Gly-Pro或药学上可接受的盐-1〜10g / l;或尼泊金-0.9÷1.1克/升作为防腐剂，蒸馏水-高达1升7。一种制备用于预防和治疗高胆固醇血症的药物组合物的方法，包括将活性物质和赋形剂混合，其特征在于该肽使用通式Arg-Pro-Gly-Pro或药学上可接受的溶胶作为活性物质。8。 8.根据权利要求7所述的方法，其特征在于，所述肽或其药学上可接受的盐的含量为0.1÷1.0重量％。 9.根据权利要求7或8所述的方法，其特征在于，所述组合物以适合于鼻内静脉注射的形式制备。10。 10.根据权利要求9所述的方法，其中

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