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首页> 外文期刊>The American Journal of Cardiology >Meta-Analysis of Usefulness of Treatment of Hypercholesterolemia With Statins for Primary Prevention in Patients Older Than 75 Years
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Meta-Analysis of Usefulness of Treatment of Hypercholesterolemia With Statins for Primary Prevention in Patients Older Than 75 Years

机译：荟萃分析治疗高胆固醇血症的有用性，患有75岁的患者初级预防

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Clinical guidelines from the United States and Europe do not recommend treatment with statins for primary prevention in patients with hypercholesterolemia who are older than 75 years. Data from 35 randomized controlled trials in this age group where statin therapy for primary prevention was compared with placebo or usual care were analyzed. Using all-cause death as the outcome, we performed 2 types of analyses: frequentist and Bayesian. Frequentist analysis indicated no significant difference in mortality between cases (on statins) and controls (on placebo or usual care, p = 0.16). However, in the Bayesian analysis, patients >75 years had lower mortality from treatment with statins (p = 0.03). In conclusion, Bayesian analysis indicates a definite, statistically significant and clinically relevant benefit of statin treatment for primary prevention in patients >75 years of age. (C) 2020 Elsevier Inc. All rights reserved.
机译：来自美国和欧洲的临床指南不建议使用他汀类药物治疗，用于患有75岁的高胆固醇血症患者的初级预防。 在该年龄组中的35例随机对照试验中的数据与分析安慰剂或通常的护理进行了对初步预防初级预防的靶标治疗。 使用全因死亡作为结果，我们进行了2种类型的分析：频率和贝叶斯。 频率分析表明病例之间的死亡率差异没有显着差异（在他汀类药物）和对照之间（在安慰剂或通常的护理，P = 0.16）。 然而，在贝叶斯分析中，患者> 75岁的死亡率降低了他汀类药物（P = 0.03）。 总之，贝叶斯分析表明他汀类药物治疗患者初级预防患者的明确，统计学显着，临床相关益处> 75岁。 （c）2020 Elsevier Inc.保留所有权利。

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