首页> 外国专利> Composition for the prevention and treatment of diabetic complications containing the extracts or fractions of Brandisia hancei Hook. f. as active ingredient

Composition for the prevention and treatment of diabetic complications containing the extracts or fractions of Brandisia hancei Hook. f. as active ingredient

机译：用于预防和治疗糖尿病并发症的组合物，其包含白兰地氏钩的提取物或级分。 F。作为有效成分

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The invention Mill currency ( Brandisia hancei Hook f. ) extract or composition for the prevention and treatment of diabetic complications, comprising as an active ingredient fractions thereof relates to , and more specifically, the wheat extract or fractions thereof currency inhibit the activity of the generation and the Al dose reductase in the indicator of diabetic complications of advanced glycation endproducts , and indicate a strong effect on diabetic complications, including diabetic retinopathy therefore , the composition for prevention and treatment of diabetic complications may be useful as the active ingredient . ;

机译：预防和治疗糖尿病并发症的发明米尔币（ Brandisia hancei Hook f。）提取物或组合物作为活性成分的小麦提取物，或其馏分作为活性成分，在晚期糖化终产物的糖尿病并发症指标中抑制了小麦的产生及其铝剂量还原酶的活性，并表现出强烈的作用。糖尿病并发症，包括糖尿病性视网膜病，因此，用于预防和治疗糖尿病并发症的组合物可用作有效成分。 ; 展开▼

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公开/公告号KR101366611B1

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公开/公告日2014-02-26

原文格式PDF

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申请/专利号KR20110081697

发明设计人 정동호;김진숙;김찬식;김정현;손은진;이윤미;김영숙;
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申请日2011-08-17

分类号A61K36/80;A61P3/10;A61P3/00;

国家 KR

入库时间 2022-08-21 15:41:27

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1. 采用复方生药提取物作为有效成分而用于防治糖尿病或者糖尿病并发症的组合物 [P] . 中国专利： CN101987169A . 2011-03-23

2. 含有传统东方药物提取物或其部位作为活性成分、用于预防和治疗糖尿病并发症的药物组合物 [P] . 中国专利： CN103874500A . 2014-06-18

3. COMPOSITION FOR PREVENTING AND TREATING COMPLICATIONS OF DIABETES MELLITUS, CONTAINING BRANDISIA HANCEI HOOK. F. EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT [P] . 世界知识产权组织专利： WO2012023803A3 . 2012-05-03

机译：预防和治疗糖尿病的并发症，包含 Brandisia Hancei 钩。 F.提取或提取其中的有效成分

4. COMPOSITION FOR PREVENTING AND TREATING COMPLICATIONS OF DIABETES MELLITUS, CONTAINING BRANDISIA HANCEI HOOK. F. EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT [P] . 世界知识产权组织专利： WO2012023803A2 . 2012-02-23

机译：预防和治疗糖尿病的并发症，包含 Brandisia Hancei 钩。 F.提取或提取其中的有效成分

5. COMPOSITION CONTAINING BRANDISIA HANCEI HOOK. F. EXTRACT OR FRACTION THEREOF FOR PREVENTING AND TREATING DIABETES COMPLICATION [P] . 韩国专利： KR20120017009A . 2012-02-27

机译：包含洋紫苏洋甘菊钩的成分。 F.为预防和治疗糖尿病并发症而进行的提取或提取

1. Ameliorative effect of alkaloid extract of Cyclea peltata (Poir.) Hook. f. Thoms. roots (ACP) on APAP/CCl4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property [J] . Varghese Jancy Shine, Somasekharan Nair Rajam Suja, Gangadharan Indira Anuja, 亚太热带生物医学杂志（英文版） . 2014,第002期

2. Chemical composition and larvicidal activity of leaf essential oil from Clausena anisata (Willd.)Hook. f. exBenth (Rutaceae) against three mosquito species [J] . Marimuthu Govindarajan 亚太热带医药杂志（英文版） . 2010,第011期

3. Effect of methanolic extract of Tetrapleura tetraptera (Schum and Thonn) Taub leaves on hyperglycemia and indices of diabetic complications in alloxan-induced diabetic rats [J] . Sunday Ene-Ojo Atawodi, Ojochenemi Ejeh Yakubu, Mubarak Labaran Liman, 亚太热带生物医学杂志（英文版） . 2014,第004期

4. Effect of methanolic extract of Tetrapleura tetraptera(Schum and Thonn)Taub leaves on hyperglycemia and indices of diabetic complications in alloxan-induced diabetic rats [J] . Sunday Ene-Ojo Atawodi, Ojochenemi Ejeh Yakubu, Mubarak Labaran Liman, 亚太热带生物医学杂志：英文版 . 2014,第004期

5. Active ingredients of traditional Chinese medicine in the treatment of diabetes and diabetic complications [J] . ZhangT.-T., JiangJ.-G. Expert opinion on investigational drugs . 2012,第11期

6. TREATMENT OF SKIN CHRONIC WOUNDS IN ELDERLY PATIENTS WITH TOPICAL PHARMACEUTICAL COMPOSITION CONTAINING AS ACTIVE INGREDIENT A MIXTURE OF POLLEN EXTRACT AND VEGETABLE OIL UNSAPONIFIABLES: PRELIMINARY DATA ON A PERSONAL SERIES [J] . Ragno A., Marsili D., Martin L. S. M., Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society . 2015,第4期

7. Normalizing effects of Costus speciosus rhizome crude extracts and its fractions on diabetic complications in STZ-induced diabetic rats [J] . Medicinal Chemistry Research . 2011,第7期

8. The Active Compounds Composition and Antifeedant Activity of Leaf Extract of Two Cultivar Caricapapaya L. on Spodoptera litura F. Larvae [C] . Sofia Ery Rahayu, Amin Setyo Leksono, Zulfaidah Penata Gama, International Conference on Life Sciences and Technology . 2020

9. Investigation of the sedative effects and mechanisms of a herbal extract ECBRC-AG and its active ingredient myricetin [D] . Zhang, Xiaohu. 2008

10. Whole Alga Algal Extracts and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus [O] . Aránzazu Bocanegra, Adrián Macho-González, Alba Garcimartín, 2021

11. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

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