PURPOSE: A porous biodegradable synthetic polymer/sol-gel derived silica membrane is provided to uniformly distribute nanosized bioactive silica in a biodegradable synthetic polymer base and maintain the mesoporous property of the bioactive silica, thereby having excellent mechanical property and biological property. CONSTITUTION: A manufacturing method of a porous biodegradable synthetic polymer/sol-gel derived silica membrane comprises: a step of manufacturing a biodegradable synthesis polymer solution by melting biodegradable synthetic polymers in a mixed solution of a nonsolvent and a solvent; a step of manufacturing a composite solution by adding drug after the biodegradable synthesis polymer solution and bioactive silica sol are mixed; and a step of removing the solvent in the composite solution. [Reference numerals] (AA) PCL/DCE/DMF solution; (BB) Bioactive silica sol; (CC) Stirring magnets for 24 hours; (DD) Bioactive silica sol uniformly dispersed in a PCL/DCE/DMF solution; (EE) Adding chemicals; (FF) Solvent casting; (GG) Maintaining at room temperature for 24 hours; (HH) Drying; (II) PCL/Bioactive silica support membrane
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