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ALLERGEN COMPLEX PRODUCED BY CONJUGATING VIBRIO VULNIFICUS FLAGELLIN AND ALLERGEN, AND THE MUCOSAL ALLERGEN-SPECIFIC IMMUNOTHERAPEUTIC AGENT CONTAINING THE SAME AS AN ACTIVE INGREDIENT
ALLERGEN COMPLEX PRODUCED BY CONJUGATING VIBRIO VULNIFICUS FLAGELLIN AND ALLERGEN, AND THE MUCOSAL ALLERGEN-SPECIFIC IMMUNOTHERAPEUTIC AGENT CONTAINING THE SAME AS AN ACTIVE INGREDIENT
The present invention relates to a conjugate prepared by conjugating mucosal vaccine adjuvants and allergen, and an allergen-specific immunotherapeutic agent; more specifically, to a conjugate prepared by using flagellin of vibrio vulnificus, which is a toll-like receptor-5 (TLR-5) drug and a vaccine adjuvant, and a hydrophilic multiple-bonded linker having a thiol group (-SH) of a dust mite extract; and a mucosal allergen-specific immunotherapeutic agent containing the same. [Reference numerals] (AA) Penh value (% relative to PBS); (BB) FlaB/HDM (10 g) mixture; (CC) FlaB/HDM (3.5 g) mixture; (DD) FlaB-HDM (3.5 g) bonded body; (EE) Methacholine (mg/mL)
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