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ANTIBODY GENERATION FROM PLASMACYTOMA-PRONE TRANSGENIC ANIMALS
ANTIBODY GENERATION FROM PLASMACYTOMA-PRONE TRANSGENIC ANIMALS
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机译:疟原虫转基因动物的抗体生成
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摘要
Certain transgenic animals which are prone to the rapid cell division of their antibody-secreting cells have superior properties for the generation of monoclonal antibodies. Not only can their antibody producing cells can be made into hybridomas with superior growth to hybridomas from non-prone animals, but the antibody producing cells themselves can be cultured directly without cell fusion or further manipulation. Disclosed herein are methods of making monoclonal antibodies comprising exposing the transgenic animals disclosed herein to an antigen and extracting antigen-specific antibody secreting cells from the transgenic animal.
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