首页> 外国专利> Formulation comprising 1 h - quinazoline - 2, 4 - dione ampa receptor antagonists, in the form of immediate release tablets and preparation thereof

Formulation comprising 1 h - quinazoline - 2, 4 - dione ampa receptor antagonists, in the form of immediate release tablets and preparation thereof

机译:速释片剂形式的包含1 h-喹唑啉-2,4-二酮安培受体拮抗剂的制剂及其制备

摘要

Disclosed herein is a tablet comprising a hydroxypropylcellulose and an active ingredient selected from compounds of Formula (I) and salts thereof: wherein R1 represents CF3, CHF2, CH2F, CH3CHF-, CH3CF2-, ethyl or iso-propyl and R2 represents alkyl substituted by one or more substituents, the substituents being defined in the specification, and whereby the heterocycle is bound to the phenyl ring by a carbon-atom. Also disclosed is a process for preparing the above tablet. In one embodiment the compound it N-{ 6-[3-(1-hydroxy-ethyl)-phenyl]-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl} -methanesulfonamide.
机译:本文公开了一种片剂,其包含羟丙基纤维素和选自式(I)化合物及其盐的活性成分:其中R 1代表CF 3,CHF 2,CH 2 F,CH 3 CHF-,CH 3 CF 2-,乙基或异丙基,并且R 2代表被一个或多个取代基,所述取代基在说明书中定义,并且由此杂环通过碳原子键合至苯环。还公开了制备上述片剂的方法。在一个实施方案中,该化合物为N- {6- [3-(1-(羟乙基)-苯基] -2,4-二氧代-7-三氟甲基-1,4-二氢-2H-喹唑啉-3-基}-甲磺酰胺。

著录项

  • 公开/公告号NZ600717A

    专利类型

  • 公开/公告日2014-06-27

    原文格式PDF

  • 申请/专利权人 NOVARTIS AG;

    申请/专利号NZ20100600717

  • 申请日2010-12-21

  • 分类号A61K9/14;A61K9/16;A61K9/20;A61K31/517;C07D239/96;

  • 国家 NZ

  • 入库时间 2022-08-21 15:56:49

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