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Methods for assessing mineralocorticoid (mr) receptor activation and for predicting the responsiveness of a patient to a treatment with mr antagonist or an aldosterone synthase inhibitor and use of an mr antagonist or an aldosterone synthase inhibitor for the preparation of medicaments
Methods for assessing mineralocorticoid (mr) receptor activation and for predicting the responsiveness of a patient to a treatment with mr antagonist or an aldosterone synthase inhibitor and use of an mr antagonist or an aldosterone synthase inhibitor for the preparation of medicaments
The present invention relates to the use of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and/or SERPINA3 as biomarkers of the Mineralocorticoid Receptor (MR) activation in a patient. More particularly, the present invention relates to a method for predicting the responsiveness of a patient to a treatment with a MR antagonist or an aldosterone synthase inhibitor, said method comprising determining in a biological sample obtained from said patient the expression level of the NGAL gene and/or of the SERPINA3 gene.
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