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NAZAL TESTOSTERONE GELS WITH CONTROLLED SHIPPING, METHODS OF PORNASAL INTRODUCTION AND PRELIMINARY FILLED MULTI-APPLICATED APPLICATOR SYSTEMS FOR PORNINAL INTRODUCTION
NAZAL TESTOSTERONE GELS WITH CONTROLLED SHIPPING, METHODS OF PORNASAL INTRODUCTION AND PRELIMINARY FILLED MULTI-APPLICATED APPLICATOR SYSTEMS FOR PORNINAL INTRODUCTION
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机译：纳斯塔尔睾丸激素控制出货，鼻孔引种方法和初次填充多应用涂药器系统
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摘要
The present invention relates to intranasal testosterone gels for the controlled release of testosterone into the systemic circulation of male and female subjects, ensuring constant effective blood levels of testosterone that do not cause unwanted bursts of testosterone in the blood after pernasal administration. The intranasal testosterone gels of the present invention are safe, convenient to use, well tolerated, stable and can be easily and reproducibly produced on an enlarged scale. In addition, since it is believed that testosterone levels above normal and below normal are presumably minimized or avoided, and serum testosterone levels are expected to remain substantially constant over the duration of the dose, i.e. intranasal testosterone gels according to the present invention mimic or restore blood testosterone levels to normal physiological levels of testosterone with a daily rhythm, these new intranasal testosterone gels are very suitable for replacement or additional testosterone therapy and are effective for treating male subjects who are diagnosed, for example, testosterone deficiency, in particular low libido, low sex drive, low sexual activity, low fe cialism low spermatogenesis aspermatogenez, depression, and / or hypogonadism, and female subjects who have diagnosed, e.g., female sexual dysfunction, in particular low libido, low sexual desire, low sexual activity, low
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