首页> 外国专利> Method for improving Optical or relieve a disorder or its related symptoms in a Target organism without folic acid deficiencies through the Administration of one or more compounds of folate downstream.

Method for improving Optical or relieve a disorder or its related symptoms in a Target organism without folic acid deficiencies through the Administration of one or more compounds of folate downstream.

机译:通过向下游施用一种或多种叶酸化合物来改善目标有机体的光学或缓解疾病或相关症状而无叶酸缺乏的方法。

摘要

The present invention relates to methods for treating optic disorders or for reducing or alleviating the signs, symptoms, or pathological conditions related to such optic disorders. In particular, methods are provided for treating optic disorders, or reducing the symptoms thereof, the methods involving the administration of one or more downstream folate compounds and/or methyl-B12. In one particular embodiment, the method comprises administration of L-methylfolate. In other embodiments, the method involves administering both L-methylfolate and methyl-B12. In still further embodiments, the method further involves reducing dietary intake of folic acid. In certain embodiments, the method further involves identifying a subject organism with a malfunction in one or more of the folate or B4 cycles. In certain embodiments, such a malfunction is one or more of the C677T and A1298C mutations. In still further embodiments, the method further involves identifying a subject organism that is deficient in vitamins B-12 and D3 but which possesses excess homocysteine.
机译:本发明涉及治疗视神经疾病或减轻或减轻与这类视神经疾病有关的体征,症状或病理状况的方法。特别地,提供了用于治疗视神经疾病或减轻其症状的方法,该方法包括给予一种或多种下游叶酸化合物和/或甲基-B12。在一个特定的实施方案中,该方法包括施用L-甲基叶酸。在其他实施方案中,该方法包括同时施用L-甲基叶酸和甲基-B12。在另外的实施方案中,该方法进一步包括减少饮食中叶酸的摄入。在某些实施方案中,该方法进一步包括鉴定在叶酸或B4循环中的一个或多个中具有功能障碍的对象生物。在某些实施方案中,这种故障是C677T和A1298C突变中的一种或多种。在另外的实施方案中,该方法进一步包括鉴定缺乏维生素B-12和D3但具有过量同型半胱氨酸的受试生物。

著录项

  • 公开/公告号CL2012003636A1

    专利类型

  • 公开/公告日2014-02-14

    原文格式PDF

  • 申请/专利权人 BUELL BRIAN;GLOBAL HEALTHCARE FOCUS LLC;

    申请/专利号CL20120003636

  • 发明设计人 BUELL BRIAN;

    申请日2012-12-21

  • 分类号A61K31/4415;A61K31/519;A61K31/714;A61K38/00;A61P27/02;

  • 国家 CL

  • 入库时间 2022-08-21 15:58:28

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