首页> 外国专利> LIPASE, METHOD FOR DETERMINING PERFORMANCE OF IN VITRO DIGESTION OF A LIPASE IN COMPARISON WITH A REFERENCE LIPASE, USE OF A LIPASE OR MIX OF LIPASES, PHARMACEUTICAL COMPOSITION, AND A METHOD FOR DISEASE TREATMENT

LIPASE, METHOD FOR DETERMINING PERFORMANCE OF IN VITRO DIGESTION OF A LIPASE IN COMPARISON WITH A REFERENCE LIPASE, USE OF A LIPASE OR MIX OF LIPASES, PHARMACEUTICAL COMPOSITION, AND A METHOD FOR DISEASE TREATMENT

机译：脂酶，与参考脂酶相比测定脂酶体外消化性能的方法，使用脂酶或脂酶的混合酶，药物成分和疾病治疗方法

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摘要

The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, with at least substitutions N33Q, T231R, N233R and D254S optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.

机译：涉及嗜热单胞菌（Humicola lanuginosa）脂肪酶的脂肪酶的药物用途，所述脂肪酶包含SEQ ID NO：2的氨基酸1-269，其至少具有取代N33Q，T231R，N233R和D254S，任选地与蛋白酶和/或淀粉酶组合。医学上的适应症包括：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病。本发明的脂肪酶具有例如改进的体外消化性能，在中性范围内的pH下的活性提高，在低pH下的稳定性提高，对蛋白酶降解稳定和/或在存在以下条件下稳定。胃蛋白酶和胆汁盐。本发明还涉及确定脂肪酶在体外的消化性能的方法，以及T.lanuginosus的脂肪酶的某些新的变体。

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公开/公告号BRPI0721103A2

专利类型
公开/公告日2014-03-04

原文格式PDF
申请/专利权人 NOVOZYMES A/S;NOVOZYMES INC.;SOLVAY PHARMACEUTICALS GMBH;
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申请/专利号BR2007PI21103
发明设计人 ALLAN SVENDSEN;DEBBIE YAVER;NINA LUNDIN;MICHAEL LAMSA;PETER COLIN GREGORY;MICHAEL SKJOET;LARS LEHMANN HYLLING CHRISTENSEN;SIGNE ESKILDSEN LARSEN;
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申请日2007-12-12
分类号C12N9/20;A61K38/46;A61K38/54;
国家 BR
入库时间 2022-08-21 15:58:36

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