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Classifying Skin Lesions Using Mass Spectrometry Proteomic Approach
Classifying Skin Lesions Using Mass Spectrometry Proteomic Approach
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机译:使用质谱蛋白质组学方法对皮肤病变进行分类
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摘要
The present invention provides for a mass spectrometry proteomic approach to distinguishing Spitz nevi from Spitzoid malignant melanoma. Histology directed mass spectral profiling allows for targeted analysis of sites of melanocytic lesion within formalin-fixed, paraffin embedded excisional biopsies. The classification system identified 5 peptide peaks, of which two have been identified as originating from vimentin and actin. A sensitivity and specificity for Spitz nevi of 97% and 90%, respectively, were achieved.
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