首页> 外国专利> MODIFYING SINGLE PROTEINS (GPCR), LIGANDS, AND NANOPORE SURFACES TO CREATE BINDING-INDUCED MOLECULAR CHANGES OF PROTEIN-LIGAND COMPLEXES DETECTED IN NANOCHANNEL TRANSLOCATION

MODIFYING SINGLE PROTEINS (GPCR), LIGANDS, AND NANOPORE SURFACES TO CREATE BINDING-INDUCED MOLECULAR CHANGES OF PROTEIN-LIGAND COMPLEXES DETECTED IN NANOCHANNEL TRANSLOCATION

机译：修饰单个蛋白质（GPCR），配体和纳米孔表面，以形成结合引起的在纳米通道转运中检测到的蛋白质-配体复合物的分子变化

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摘要

A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.

机译：提供了一种利用纳米装置来区分具有不同结构的分子的机制。分子易位穿过或跨过充满电解质溶液的纳米通道。对于每个移位事件，都会测量通过纳米通道的电信号。纳米通道的内表面包括功能层，该功能层是使纳米通道功能化的涂层，其中功能层被配置为在移位事件中与预定的分子相互作用。基于与功能层相互作用以改变电信号和/或改变易位事件的易位时间的分子中的预定分子，确定形成至少两种不同分子的组合。

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公开/公告号US2014179541A1

专利类型
公开/公告日2014-06-26

原文格式PDF
申请/专利权人 INTERNATIONAL BUSINESS MACHINES CORPORATION;THE UNIVERSITY OF MELBOURNE;FLOREY INSTITUTE OF NEUROSCIENCE & MENTAL HEALTH;
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申请/专利号US201213727090
发明设计人 JOHN WAGNER;MATTHEW DOWNTOWN;NATALIE GUNN;PRISCILLA ROGERS;DANIEL JAMES SCOTT;STAN SKAFIDAS;STEFAN HARRER;ROSS BATHGATE;
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申请日2012-12-26
分类号G01N33/53;
国家 US
入库时间 2022-08-21 16:08:03

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