首页> 外国专利> POLYNUCLEOTIDE ENCODING MUTANT RECOMBINANT IgA1 PROTEASE OF Neisseria meningitidis OF SEROGROUP B, RECOMBINANT PLASMID DNA COMPRISING SAID POLYNUCLEOTIDE, HOST CELL CONTAINING SAID PLASMID DNA, RECOMBINANT IgA1 PROTEASE OF Neisseria memingitidis OF SEROGROUP B, METHOD OF PRODUCING MATURE FORM OF IgA1 PROTEASE

POLYNUCLEOTIDE ENCODING MUTANT RECOMBINANT IgA1 PROTEASE OF Neisseria meningitidis OF SEROGROUP B, RECOMBINANT PLASMID DNA COMPRISING SAID POLYNUCLEOTIDE, HOST CELL CONTAINING SAID PLASMID DNA, RECOMBINANT IgA1 PROTEASE OF Neisseria memingitidis OF SEROGROUP B, METHOD OF PRODUCING MATURE FORM OF IgA1 PROTEASE

机译：编码脑膜炎奈瑟氏球菌脑膜炎奈瑟氏球菌突变型重组IgA1蛋白酶的多核苷酸，包含所述多核苷酸的重组质粒DNA，包含所述质粒DNA的宿主细胞，血清型奈瑟氏球菌的重组IgA1蛋白酶解的浆液性抗体。

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FIELD: biotechnology.;SUBSTANCE: proposed enzymatically inactive IgA1 protease with replacement Ser267Ala for use as a component of a polyvalent vaccine designed to protect people against meningococcal infection and other microorganisms, which pathogenicity is caused by IgA1 protease. The invention includes a polynucleotide encoding the said mutant form of IgA1 protease of Neisseria meningitidis of serogroup B, comprising the said polynucleotide, a recombinant plasmid DNA, the strain Escherichia coli - producer of a mutant form of IgA1 protease according to the invention, the method of preparing a recombinant form of the enzyme using a technology of recombinant DNA, and recombinant inactivated IgA1 protease.;EFFECT: increased level of immunogenicity.;6 cl, 1 tbl, 5 dwg, 7 ex

机译：领域：拟议中的具有酶促活性的IgA1蛋白酶，具有替代性Ser267Ala替代品，可作为多价疫苗的成分使用，该疫苗旨在保护人们免受脑膜炎球菌感染和其他微生物的侵害，其致病性是由IgA1蛋白酶引起的。本发明包括编码所述血清群B的脑膜炎奈瑟氏球菌的IgA1蛋白酶的所述突变形式的多核苷酸，其包含所述多核苷酸，重组质粒DNA，大肠杆菌菌株-根据本发明的IgA1蛋白酶的突变形式的产生者，所述方法重组DNA技术和重组灭活的IgA1蛋白酶制备酶的重组形式的研究;效果：提高了免疫原性水平; 6 cl，1 tbl，5 dwg，7 ex

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公开/公告号RU2486243C1

专利类型
公开/公告日2013-06-27

原文格式PDF
申请/专利权人 FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE NAUKI INSTITUT BIOORGANICHESKOJ KHIMII IM. AKADEMIKOV M.M. SHEMJAKINA I JU.A.OVCHINNIKOVA ROSSIJSKOJ AKADEMII NAUK (IBKH RAN);
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申请/专利号RU20110143071
发明设计人 RUMSH LEV DAVYDOVICH;SEROVA OKSANA VIKTOROVNA;ZINCHENKO ALEKSEJ ALEKSEEVICH;ALLILUEV ALEKSANDR PAVLOVICH;KOZLOV LEONID VASILEVICH;KOTELNIKOVA OLGA VIKTOROVNA;ZHIGIS LARISA STEFANOVNA;JAGUDAEVA ELENA JUREVNA;ANDINA SVETLANA SEMENOVNA;ANOKHINA IRINA VIKTOROVNA;ZUEVA VERA SERGEEVNA;GORDEEVA ELENA ANATOLEVNA;MELIKHOVA TATJANA DMITRIEVNA;NOKEL ELENA ADAMOVNA;
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申请日2011-10-26
分类号C12N9/50;C12N15/09;C12N15/57;C12P21/02;
国家 RU
入库时间 2022-08-21 16:22:59

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