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The coated scaffold for regeneration of hard tissue with components of bone matrix containing mesoporous bioactive glass by co-precipitation and the method thereof

机译:用于共沉淀的含有中孔生物活性玻璃的骨基质成分的硬组织再生涂层支架及其方法

摘要

PURPOSE: A support for regeneration of hard tissue is provided to have high osteanagenesis inductive effect. CONSTITUTION: A manufacturing method of A support for regeneration of hard tissue comprises: a step of synthesizing template solution by solving a block copolymer into solvent including alcohol; a step of synthesizing porosity bioactive glass solution, by mixing silicon compound, a calcium compound, and a phosphorus compound with the template solution; a step of obtaining porous bioactive glass by drying and plasticizing the porous bioactive glass solution; a step of shattering the porous bioactive glass to the size of submicron; a step of obtaining paste by mixing the porous bioactive glass with a biodegradable polymer; a step of manufacturing a support by laminating-shaping the paste; a step of cleaning and drying the support; a step coating the surface of the support, in which solvent is removed, with components of bone matrix by using co-precipitation; a step of cleaning and drying the coated support; and a step of sterilizing and drying the support.
机译:目的:提供了对硬组织再生的支持,以具有高的成骨诱导作用。构成:一种用于硬组织再生的载体的制造方法,包括:通过将嵌段共聚物溶解在包括醇的溶剂中来合成模板溶液的步骤;通过将硅化合物,钙化合物和磷化合物与模板溶液混合来合成多孔生物活性玻璃溶液的步骤;通过干燥和增塑多孔生物活性玻璃溶液获得多孔生物活性玻璃的步骤;将多孔生物活性玻璃粉碎至亚微米尺寸的步骤;通过将多孔生物活性玻璃与可生物降解的聚合物混合而获得糊剂的步骤;通过将糊剂层压成型来制造支撑体的步骤;清洁和干燥载体的步骤;通过共沉淀用骨基质的成分涂覆去除溶剂的载体表面的步骤;清洁和干燥涂覆的载体的步骤;以及对载体进行灭菌和干燥的步骤。

著录项

  • 公开/公告号KR101243956B1

    专利类型

  • 公开/公告日2013-03-18

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20100065388

  • 发明设计人 윤희숙;

    申请日2010-07-07

  • 分类号A61L27/56;A61L27/32;A61L27/40;A61F2/02;

  • 国家 KR

  • 入库时间 2022-08-21 16:25:33

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