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Immunogenic proteins form genome-derived outer membrane of leptospira and compositions and methods based thereon
Immunogenic proteins form genome-derived outer membrane of leptospira and compositions and methods based thereon
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机译:免疫原性蛋白质形成钩端螺旋体的基因组来源的外膜以及基于其的组合物和方法
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摘要
Leptospira outer membrane protein (OMP) LP1118 is provided. The OMP can be used as a tool for developing effective vaccines or diagnostic methods for leptospirosis. Expression vectors for the OMP gene are further provided. The antigenic properties of the Leptospira OMP can be used to create, manufacture or improve vaccines. Vaccines, including but not limited to DNA vaccines, recombinant vaccines, and T-cell epitope vaccines based on the foregoing OMP are also provided. Methods for producing such vaccines are also provided. Also provided are methods for using Leptospira OMP genes, proteins and antibodies for therapeutic treatment and serological diagnosis techniques.
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