首页> 外国专利> METHODS OF DIAGNOSING INFLAMMATORY DISEASES BY DETERMINING PYROGLUTAMATE-MODIFIED MCP-1 AND SCREENING METHODS FOR INHIBITORS OF GLUTAMINYL CYCLASE

METHODS OF DIAGNOSING INFLAMMATORY DISEASES BY DETERMINING PYROGLUTAMATE-MODIFIED MCP-1 AND SCREENING METHODS FOR INHIBITORS OF GLUTAMINYL CYCLASE

机译：确定焦谷氨酸修饰的MCP-1诊断炎症性疾病的方法和筛选谷氨酰胺基环化酶抑制剂的筛选方法

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摘要

The invention relates to a method to monitor treatment of an inflammatory disease or an inflammatory associated disease with the use of the ratio of N-terminal pyroglutamate modified MCP-1 (MCP-1 N1pE) : total concentration of MCP-1 within a biological sample as a biomarker and further concerns a novel method to determine the proportion of N-terminal pyroglutamate modified MCP-1 in relation to the total concentration of MCP-1 in biological samples. The invention also provides a diagnostic kit and a method for screening a glutaminyl cyclase (QC) inhibitor or measuring the effectiveness of a glutaminyl cyclase (QC) inhibitor.

机译：本发明涉及一种利用N末端焦谷氨酸修饰的MCP-1（MCP-1N1pE）的比率监测炎性疾病或炎性相关疾病的治疗的方法：生物样品中MCP-1的总浓度作为生物标志物，并且进一步涉及确定生物样品中N末端焦谷氨酸修饰的MCP-1相对于MCP-1总浓度的比例的新方法。本发明还提供了用于筛选谷氨酰胺酰环化酶（QC）抑制剂或测量谷氨酰胺酰环化酶（QC）抑制剂的诊断试剂盒和方法。

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公开/公告号EP2537029A1

专利类型
公开/公告日2012-12-26

原文格式PDF
申请/专利权人 PROBIODRUG AG;
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申请/专利号EP20110703712
发明设计人 DEMUTH HANS-ULRICH;GANS KATHRIN;CYNIS HOLGER;KLEINSCHMIDT MARTIN;TAUDTE NADINE;RAHFELD JENS-ULRICH;
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申请日2011-02-18
分类号G01N33/574;G01N33/68;
国家 EP
入库时间 2022-08-21 16:31:38

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