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PROCESS FOR THE PREPARATION OF 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATES

机译:制备4-(1-羟基-1-甲基乙基)-2-丙基-咪唑-5-羧酸酯的方法

摘要

The present invention discloses a process for obtaining 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate (formula I) by the reaction of 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole (formula II), or its hydrolysis product, or its ring-opening product, with alcohol under appropriate catalytic conditions. Furthermore, the present invention also provides a process for obtaining high purity 4,4-dimethyl-2-propyl-4,6-dihydrofuro[3,4-d]imidazole (formula II), therefore purified compound of formula I can be produced. Producing of olmesartan medoxomil at high purity is assured by said processes. R in formula I is selected from C1-C6 alkyl.
机译:本发明公开了一种通过4,4-二甲基-2-丙基-4,6的反应获得4-(1-羟基-1-甲基乙基)-2-丙基-咪唑-5-羧酸酯(式I)的方法-二氢呋喃[3,4-d]咪唑(式II),或其水解产物,或其开环产物,在适当的催化条件下与醇反应。此外,本发明还提供了获得高纯度的4,4-二甲基-2-丙基-4,6-二氢呋喃[3,4-d]咪唑(式II)的方法,因此可以制备纯化的式I化合物。所述方法确保了高纯度的奥美沙坦酯的生产。式I中的R选自C 1 -C 6 烷基。

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