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SUPERPARAMAGNETIC NANOPARTICLES BASED ON IRON OXIDES WITH MODIFIED SURFACE, METHOD OF THEIR PREPARATION AND APPLICATION

机译:基于铁氧化物修饰表面的超顺磁性纳米粒子及其制备方法和应用

摘要

The invention concerns superparamagnetic nanoparticle probes based on ironoxides withmodified surface, method of their preparation and application. The probe ismodified on itssurface by a modification agent selected from the group consisting of mono-,di- andpolysaccharides, poly(amino acid)s and polymers of (meth)acrylic acidderivatives, and form acolloid consisting of particles with narrow size distribution withpolydispersity index lower than1.3, the average size of which ranges from 10 to 30 nm, iron oxide contentamounts to 70-99.9wt.%, the modification agent content makes 0.1-30 wt.%. The probes can be usedfor labellingcells used in magnetic resonance imaging for monitoring their movement,localization, survivaland differentiation especially in detection of pathologies with celldysfunction and of tissueregeneration and also for labelling and monitoring cells administered for celltherapy purposes inthe recipient organism by magnetic resonance.
机译:本发明涉及基于铁的超顺磁性纳米粒子探针与氧化物改性表面,其制备方法和应用。探头是对其进行了修改表面改性剂选自单,和多糖,聚(氨基酸)和(甲基)丙烯酸聚合物派生,并形成一个胶体由粒径分布窄的颗粒组成,多分散指数低于1.3,平均尺寸为10至30 nm,氧化铁含量达到70-99.9重量%,改性剂含量为0.1-30重量%。可以使用探头用于标签磁共振成像中用于监测其运动的细胞,本地化,生​​存和分化,特别是在细胞病理学检测中功能障碍和组织再生,也用于标记和监视细胞的细胞管理治疗目的通过磁共振使受体生物体。

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