首页> 外国专利> u0431u0438u043eu043cu0430u0440u043au0435u0440 high adaptation and for detection of pulmonary edema

u0431u0438u043eu043cu0430u0440u043au0435u0440 high adaptation and for detection of pulmonary edema

机译:u0431 u0438 u043e u043c u0430 u0440 u043a u0435 u0440具有高度适应性,可用于检测肺水肿

摘要

the invention relates to u0431u0438u043eu043cu0430u0440u043au0435u0440u0430u043c for detection sensitivity and high adaptation to hypoxia and how to obtain them.the invention, in particular,refers to the gene variants SNP id rs479200 and rs480902 first u0438u043du0442u0440u043eu043du0435 gene EGLN1 (u043fu0440u043eu043bu0438u043bu0433u0438u0434u0440u043eu043au0441u0438u043bu0430u0437u044b 2) as u0431u0438u043eu043cu0430u0440u043au0435u0440u043eu0432 adaptation to high altitude and u043fu0440u0435u0434u0440u0430u0441u043fu043eu043bu043eu0436u0435u043du043du043eu0441 t to a high-altitude edemalight and sensitivity to hypoxia.the use of which provides a new approach to the application of the concepts of u0444u0435u043du043eu0442u0438u043fu0438u0440u043eu0432u0430u043du0438u044f according to u0430u044eu0440u0432u0435u0434u0435 together with population genetics and gene u043eu043cu0438u043au043eu0439 diseases.more specifically, the - allel SNP id rs480902 and t - allel rs479200 gene EGLN1u0447u0430u0449u0435 occur in patients with u043du0430u0440u0435 (high-altitude edema) and virtually absent from the natives u0440u043du043eu0439 areas.according to the present invention also proposed u043fu0440u0430u0439u043cu0435u0440u044b and methods suitable for the detection of these u0430u043bu043bu0435u043bu044cu043du044bu0445 optionsin order to predict the individual adaptability to high altitude hypoxia and / or to the genetic analysis of the gene EGLN1u0432 populations.
机译:本发明涉及检测敏感性和对缺氧的高度适应性以及如何获得它们的方法。本发明尤其涉及该基因。变体SNP id rs479200和rs480902首个 u0438 u043d u0442 u0440 u043e u043d u0435基因EGLN1( u043f u0440 u043e u043b u0438 u043b u0433 u0438 u0434 u0440 u043e u043 u0438 u043b u0430 u0437 u044b 2)为 u0431 u0438 u043e u043c u04c u0430 u0440 u043a u0435 u0440 u043e u0432可以适应高海拔和 u043f u0440 u0435 u0434 u0440 u0430 u0441 u043f u043e u043b u043e u0436 u0435 u043d u043d u043d u043e u0441 t对低氧和对缺氧的敏感性。使用该方法提供了一种新的概念应用方法 u0444 u0435 u043d u043e u0442 u043e u043f u0438 u0440 u043e u0432 u0430 u043d u043d u0438 u044f中的所有元素遗传学和基因 u043e u043c u0438 u043a u043e u0439更具体地讲,等位基因SNP id rs480902和t-等位基因rs479200基因EGLN1 u0447 u0430 u0449 u0435发生在患有 u043d u0430 u0440 u0435(高海拔水肿)的患者中,而当地人实际上不存在 u0440 u043d u043e u0439区域。根据本发明,还提出了 u043f u0440 u0430 u0439 u043c u0435 u0440 u044b和适合于检测这些 u0430 u043b u043b u043b u0435 为了预测个人对高原缺氧和 /或对基因EGLN1 u0432种群的遗传分析的适应性,选择了u043b u044c u043d u044b u0445选项。

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