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Antiviral screening method to identify inhibitors of phosphatidylinositol 4,5-bisphosphate PI(4,5)P2 binding to the HIV gag matrix (MA) protein
Antiviral screening method to identify inhibitors of phosphatidylinositol 4,5-bisphosphate PI(4,5)P2 binding to the HIV gag matrix (MA) protein
The present invention provides for testing methods to determine an effective testing agent that affects the activity of the HIV Gag protein at the plasma membrane of a cell, and specifically, effecting changes in the structural conformation of at least one fatty acid of PI(4,5)P2, a member of a family of differentially phosphorylated phosphatidylinositides, wherein inhibition of the extension of such fatty acid into the MA domain of the Gag protein reduces binding of Gag to the plasma membrane, thereby inhibiting virus particle assembly and subsequent replication of the HIV virus.
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