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Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein

机译：识别凝固酶阴性葡萄球菌蛋白的单克隆抗体

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Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis. The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided. 展开▼

机译：提供了可与表皮葡萄球菌的SdrF蛋白结合的单克隆抗体，可用于治疗和预防表皮葡萄球菌等感染葡萄球菌的感染。本发明的单克隆抗体的优点在于它们也可以识别I的结合结构域和亚结构域。除表皮蛋白 SdrF蛋白外。还提供了基于本发明的单克隆抗体的合适的组合物和被动疫苗，以及它们的使用方法。展开▼

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公开/公告号US8475798B2

专利类型

公开/公告日2013-07-02

原文格式PDF

申请/专利权人 JOSEPH M. PATTI;JEFF T. HUTCHINS;ANDREA HALL;LINDA SANTOS;MARIA BOWDEN;MAGNUS HOOK;
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申请/专利号US20060917435

发明设计人 JOSEPH M. PATTI;JEFF T. HUTCHINS;ANDREA HALL;LINDA SANTOS;MARIA BOWDEN;MAGNUS HOOK;
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申请日2006-06-16

分类号A61K39/40;A61K39;A61K39/395;G01N33/569;

国家 US

入库时间 2022-08-21 16:45:06

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1. 识别凝血酶阴性的葡萄球菌和金黄色葡萄球菌的表面蛋白的交叉反应性单克隆抗体和多克隆抗体 [P] . 中国专利： CN100359327C . 2008.01.02

2. 识别凝血酶阴性的葡萄球菌和金黄色葡萄球菌的表面蛋白的交叉反应性单克隆抗体和多克隆抗体 [P] . 中国专利： CN1543569A . 2004-11-03

3. MONOCLONAL AND POLYCLONAL ANTIBODIES RECOGNIZING COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEINS [P] . 欧洲知识产权局专利： EP1481011A4 . 2007-05-30

机译：单克隆和多克隆抗体识别凝结酶阴性葡萄球菌蛋白

4. MONOCLONAL AND POLYCLONAL ANTIBODIES RECOGNIZING COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEINS [P] . 欧洲知识产权局专利： EP1481011A1 . 2004-12-01

机译：单克隆和多克隆抗体识别凝结酶阴性葡萄球菌蛋白

5. MONOCLONAL AND POLYCLONAL ANTIBODIES RECOGNIZING COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEINS [P] . CA2478029A1 . 2003-09-18

机译：单克隆和多克隆抗体识别凝结酶阴性葡萄球菌蛋白

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